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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Proto-oncogene c-Fos

SKU : BHE13804455

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1291h
Alternative Names	Cellular oncogene fos ; G0/G1 switch regulatory protein 7 ; G0S7
Categories	Elisa
Function	Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
Specificity	Natural and recombinant Human Proto-oncogene c-Fos
Subcellular Location	Nucleus
Detection Range	0.312-20ng/mL
Entryname	FOS_HUMAN
Method Type	Sandwich
Platform	PF00170
Protein Name	Proto-oncogene c-Fos
Sensitivity	0.12ng/mL
Sequence	50: MMFSGFNADY ; EASSSRCSSA ; SPAGDSLSYY ; HSPADSFSSM ; GSPVNAQDFC ; 100: TDLAVSSANF ; IPTVTAISTS ; PDLQWLVQPA ; LVSSVAPSQT ; RAPHPFGVPA ; 150: PSAGAYSRAG ; VVKTMTGGRA ; QSIGRRGKVE ; QLSPEEEEKR ; RIRRERNKMA ; 200: AAKCRNRRRE ; LTDTLQAETD ; QLEDEKSALQ ; TEIANLLKEK ; EKLEFILAAH ; 250: RPACKIPDDL ; GFPEEMSVAS ; LDLTGGLPEV ; ATPESEEAFT ; LPLLNDPEPK ; 300: PSVEPVKSIS ; SMELKTEPFD ; DFLFPASSRP ; SGSETARSVP ; DMDLSGSFYA ; 350: ADWEPLHSGS ; LGMGPMATEL ; EPLCTPVVTC ; TPSCTAYTSS ; FVFTYPEADS ; 380: FPSCAAAHRK ; GSSSNEPSSD ; SLSSPTLLAL ;
Sequence Length	380
String	P01100
Sub Unit	Heterodimer; with JUN (By similarity). Interacts with MAFB (By similarity). Component of the SMAD3/SMAD4/JUN/FOS complex required for syngernistic TGF-beta-mediated transcription at the AP1 promoter site. Interacts with SMAD3; the interaction is weak even on TGF-beta activation. Interacts with MAFB. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA.

Uniprot	P01100
Gene Name	FOS
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2353
Unigene	Hs.25647

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SKU	Supplier No.	Size	Your price	Quantity
BHE13804455	E1291h	96T	$736		Add to Cart

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