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ELISA Kit for Human Proteinase-activated receptor 2

SKU : BHE13808579

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2022h
Alternative Names	Coagulation factor II receptor-like 1 ; G-protein coupled receptor 11 ; Thrombin receptor-like 1 ; GPR11 ; PAR2
Categories	Elisa
Function	Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilatation. Associates with a subset of G proteins alpha subunits such as G alpha-q, G alpha-11, G alpha-14, G alpha-12 and G alpha-13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. However, according to PubMed:21627585 can signal through G(i) subunit alpha. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to G alpha-q/11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of G alpha-q/11 and involves promotion of cofilin dephosphoryltaion and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as proinflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immnune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Implicated in a number of acute and chronic inflammatory diseases such as of the joints, lungs, brain, gastrointestinal tract, periodontium, skin, and vascular systems, and in autoimmune disorders.
Specificity	Natural and recombinant Human Proteinase-activated receptor 2
Subcellular Location	Cell membrane Multi-pass membrane protein
Detection Range	0.156-10ng/mL
Entryname	PAR2_HUMAN
Method Type	Sandwich
Platform	PF00001
Protein Name	Proteinase-activated receptor 2
Sensitivity	0.078ng/mL
Sequence	50: MRSPSAAWLL ; GAAILLAASL ; SCSGTIQGTN ; RSSKGRSLIG ; KVDGTSHVTG ; 100: KGVTVETVFS ; VDEFSASVLT ; GKLTTVFLPI ; VYTIVFVVGL ; PSNGMALWVF ; 150: LFRTKKKHPA ; VIYMANLALA ; DLLSVIWFPL ; KIAYHIHGNN ; WIYGEALCNV ; 200: LIGFFYGNMY ; CSILFMTCLS ; VQRYWVIVNP ; MGHSRKKANI ; AIGISLAIWL ; 250: LILLVTIPLY ; VVKQTIFIPA ; LNITTCHDVL ; PEQLLVGDMF ; NYFLSLAIGV ; 300: FLFPAFLTAS ; AYVLMIRMLR ; SSAMDENSEK ; KRKRAIKLIV ; TVLAMYLICF ; 350: TPSNLLLVVH ; YFLIKSQGQS ; HVYALYIVAL ; CLSTLNSCID ; PFVYYFVSHD ; 397: FRDHAKNALL ; CRSVRTVKQM ; QVSLTSKKHS ; RKSSSYSSSS ; TTVKTSY
Sequence Length	397
String	P55085
Sub Unit	Interacts with TLR4, COPS5 and TMED2. Interacts with GNAQ, GNA11, GNA12, GNA13 and GNA14.

Uniprot	P55085
Gene Name	F2RL1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2150
Unigene	Hs.154299

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808579	E2022h	96T	$736		Add to Cart

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