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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Protein lin-28 homolog A

SKU : BHE13806711

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1540h
Alternative Names	Zinc finger CCHC domain-containing protein 1 ; CSDD1 ; LIN28 ; ZCCHC1
Categories	Elisa
Function	Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
Specificity	Natural and recombinant Human Protein lin-28 homolog A
Subcellular Location	Cytoplasm Nucleus nucleolus Nucleolar localization observed in 10-15% of the nuclei in differentiated myotubes (By similarity). Shuttles between the cytoplasm and the nucleus. Localizes to cytoplasmic processing bodies and stress granules.
Detection Range	0.156-10ng/ml
Entryname	LN28A_HUMAN
Method Type	Sandwich
Platform	PF00313
Protein Name	Protein lin-28 homolog A
Sensitivity	0.089ng/mL
Sequence	50: MGSVSNQQFA ; GGCAKAAEEA ; PEEAPEDAAR ; AADEPQLLHG ; AGICKWFNVR ; 100: MGFGFLSMTA ; RAGVALDPPV ; DVFVHQSKLH ; MEGFRSLKEG ; EAVEFTFKKS ; 150: AKGLESIRVT ; GPGGVFCIGS ; ERRPKGKSMQ ; KRRSKGDRCY ; NCGGLDHHAK ; 200: ECKLPPQPKK ; CHFCQSISHM ; VASCPLKAQQ ; GPSAQGKPTY ; FREEEEEIHS ; 209: PTLLPEAQN
Sequence Length	209
String	Q9H9Z2
Sub Unit	During skeletal muscle differentiation, associated with translation initiation complexes in the polysomal compartment. Directly interacts with EIF3S2. Interaction with NCL is RNA-dependent (By similarity). Interacts with ZCCHC11/TUT4.

Uniprot	Q9H9Z2
Gene Name	LIN28A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:79727
Unigene	Hs.86154

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806711	E1540h	96T	$736		Add to Cart

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