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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Proliferation-associated protein 2G4

SKU : BHE13808735

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1733h
Alternative Names	Cell cycle protein p38-2G4 homolog ; hG4-1 ; ErbB3-binding protein 1 ; EBP1
Categories	Elisa
Function	May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (inteal ribosomal entry site).
Specificity	Natural and recombinant Human Proliferation-associated protein 2G4
Subcellular Location	Cytoplasm Nucleus nucleolus Tranlocates to the nucleus upon treatment with HRG.
Detection Range	0.156-10ng/mL
Entryname	PA2G4_HUMAN
Method Type	Sandwich
Platform	PF00557
Protein Name	Proliferation-associated protein 2G4
Sensitivity	0.067ng/mL
Sequence	50: MSGEDEQQEQ ; TIAEDLVVTK ; YKMGGDIANR ; VLRSLVEASS ; SGVSVLSLCE ; 100: KGDAMIMEET ; GKIFKKEKEM ; KKGIAFPTSI ; SVNNCVCHFS ; PLKSDQDYIL ; 150: KEGDLVKIDL ; GVHVDGFIAN ; VAHTFVVDVA ; QGTQVTGRKA ; DVIKAAHLCA ; 200: EAALRLVKPG ; NQNTQVTEAW ; NKVAHSFNCT ; PIEGMLSHQL ; KQHVIDGEKT ; 250: IIQNPTDQQK ; KDHEKAEFEV ; HEVYAVDVLV ; SSGEGKAKDA ; GQRTTIYKRD ; 300: PSKQYGLKMK ; TSRAFFSEVE ; RRFDAMPFTL ; RAFEDEKKAR ; MGVVECAKHE ; 350: LLQPFNVLYE ; KEGEFVAQFK ; FTVLLMPNGP ; MRITSGPFEP ; DLYKSEMEVQ ; 394: DAELKALLQS ; SASRKTQKKK ; KKKASKTAEN ; ATSGETLEEN ; EAGD
Sequence Length	394
String	Q9UQ80
Sub Unit	Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity. Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR. Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1, PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21, RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is enhanced upon PA2G4 dephosphorylation.

Uniprot	Q9UQ80
Gene Name	PA2G4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5036
Unigene	Hs.524498

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808735	E1733h	96T	$736		Add to Cart

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