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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Proliferating cell nuclear antigen

SKU : BHE13808699

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0591h
Alternative Names	Cyclin
Categories	Elisa
Function	This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2.
Specificity	Natural and recombinant Human Proliferating cell nuclear antigen
Subcellular Location	Nucleus Forms nuclear foci representing sites of ongoing DNA replication and vary in morphology and number during S phase. Together with APEX2, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
Detection Range	0.156-10ng/mL
Entryname	PCNA_HUMAN
Method Type	Sandwich
Platform	PF02747
Protein Name	Proliferating cell nuclear antigen
Sensitivity	0.083ng/mL
Sequence	50: MFEARLVQGS ; ILKKVLEALK ; DLINEACWDI ; SSSGVNLQSM ; DSSHVSLVQL ; 100: TLRSEGFDTY ; RCDRNLAMGV ; NLTSMSKILK ; CAGNEDIITL ; RAEDNADTLA ; 150: LVFEAPNQEK ; VSDYEMKLMD ; LDVEQLGIPE ; QEYSCVVKMP ; SGEFARICRD ; 200: LSHIGDAVVI ; SCAKDGVKFS ; ASGELGNGNI ; KLSQTSNVDK ; EEEAVTIEMN ; 250: EPVQLTFALR ; YLNFFTKATP ; LSSTVTLSMS ; ADVPLVVEYK ; IADMGHLKYY ; 261: LAPKIEDEEG ; S
Sequence Length	261
String	P12004
Sub Unit	Homotrimer (By similarity). Forms a complex with activator 1 heteropentamer in the presence of ATP. Interacts with EXO1, POLH, POLK, DNMT1, ERCC5, FEN1, CDC6 and POLDIP2. Interacts with APEX2; this interaction is triggered by reactive oxygen species and increased by misincorporation of uracil in nuclear DNA. Forms a ternary complex with DNTTIP2 and core histone. Interacts with KCTD10 and PPP1R15A (By similarity). Interacts with POLD1, POLD3 and POLD4. Interacts with BAZ1B; the interaction is direct. Interacts with HLTF and SHPRH. Interacts with NUDT15. Interaction is disrupted in response to UV irradiation and acetylation. Interacts with CDKN1A/p21(CIP1) and CDT1; interacts via their PIP-box which also recruits the DCX(DTL) complex. Interacts with DDX11.

Uniprot	P12004
Gene Name	PCNA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5111
Unigene	Hs.147433

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808699	E0591h	96T	$736		Add to Cart

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