Autosomal dominant polycystic kidney disease type II protein ; Polycystic kidney disease 2 protein ; Polycystwin ; R48321 ; Transient receptor potential cation channel subfamily P member 2 ; TRPP2
Categories
Elisa
Function
Functions as a calcium permeable cation channel. PKD1 and PKD2 may function through a common signaling pathway that is necessary for normal tubulogenesis.
Specificity
Natural and recombinant Human Polycystin-2
Subcellular Location
Membrane Multi-pass membrane protein Endoplasmic reticulum
Forms homooligomers. Interacts with PKD1. PKD1 requires the presence of PKD2 for stable expression. Interacts with CD2AP. Interacts with HAX1. Interacts with NEK8.