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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Poly [ADP-ribose] polymerase 1

SKU : BHE13808441

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0947h
Alternative Names	ADP-ribosyltransferase diphtheria toxin-like 1 ; ARTD1 ; NAD(+) ADP-ribosyltransferase 1 ; ADPRT 1 ; Poly[ADP-ribose] synthase 1 ; ADPRT ; PPOL
Categories	Elisa
Function	Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
Specificity	Natural and recombinant Human Poly [ADP-ribose] polymerase 1
Subcellular Location	Nucleus
Detection Range	0.625-40ng/mL
Entryname	PARP1_HUMAN
Method Type	Sandwich
Platform	PF00533
Protein Name	Poly [ADP-ribose] polymerase 1
Sensitivity	0.31ng/mL
Sequence	50: MAESSDKLYR ; VEYAKSGRAS ; CKKCSESIPK ; DSLRMAIMVQ ; SPMFDGKVPH ; 100: WYHFSCFWKV ; GHSIRHPDVE ; VDGFSELRWD ; DQQKVKKTAE ; AGGVTGKGQD ; 150: GIGSKAEKTL ; GDFAAEYAKS ; NRSTCKGCME ; KIEKGQVRLS ; KKMVDPEKPQ ; 200: LGMIDRWYHP ; GCFVKNREEL ; GFRPEYSASQ ; LKGFSLLATE ; DKEALKKQLP ; 250: GVKSEGKRKG ; DEVDGVDEVA ; KKKSKKEKDK ; DSKLEKALKA ; QNDLIWNIKD ; 300: ELKKVCSTND ; LKELLIFNKQ ; QVPSGESAIL ; DRVADGMVFG ; ALLPCEECSG ; 350: QLVFKSDAYY ; CTGDVTAWTK ; CMVKTQTPNR ; KEWVTPKEFR ; EISYLKKLKV ; 400: KKQDRIFPPE ; TSASVAATPP ; PSTASAPAAV ; NSSASADKPL ; SNMKILTLGK ; 450: LSRNKDEVKA ; MIEKLGGKLT ; GTANKASLCI ; STKKEVEKMN ; KKMEEVKEAN ; 500: IRVVSEDFLQ ; DVSASTKSLQ ; ELFLAHILSP ; WGAEVKAEPV ; EVVAPRGKSG ; 550: AALSKKSKGQ ; VKEEGINKSE ; KRMKLTLKGG ; AAVDPDSGLE ; HSAHVLEKGG ; 600: KVFSATLGLV ; DIVKGTNSYY ; KLQLLEDDKE ; NRYWIFRSWG ; RVGTVIGSNK ; 650: LEQMPSKEDA ; IEHFMKLYEE ; KTGNAWHSKN ; FTKYPKKFYP ; LEIDYGQDEE ; 700: AVKKLTVNPG ; TKSKLPKPVQ ; DLIKMIFDVE ; SMKKAMVEYE ; IDLQKMPLGK ; 750: LSKRQIQAAY ; SILSEVQQAV ; SQGSSDSQIL ; DLSNRFYTLI ; PHDFGMKKPP ; 800: LLNNADSVQA ; KVEMLDNLLD ; IEVAYSLLRG ; GSDDSSKDPI ; DVNYEKLKTD ; 850: IKVVDRDSEE ; AEIIRKYVKN ; THATTHNAYD ; LEVIDIFKIE ; REGECQRYKP ; 900: FKQLHNRRLL ; WHGSRTTNFA ; GILSQGLRIA ; PPEAPVTGYM ; FGKGIYFADM ; 950: VSKSANYCHT ; SQGDPIGLIL ; LGEVALGNMY ; ELKHASHISK ; LPKGKHSVKG ; 1000: LGKTTPDPSA ; NISLDGVDVP ; LGTGISSGVN ; DTSLLYNEYI ; VYDIAQVNLK ; 1014: YLLKLKFNFK ; TSLW
Sequence Length	1014
String	P09874
Sub Unit	Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LRIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with TIAM2 and ZNF423 (By similarity). Interacts (when poly-ADP-ribosylated) with CHD1L. Interacts with the DNA polymerase alpha catalytic subunit POLA1; this interaction functions as part of the control of replication fork progression. Interacts with EEF1A1, RNF4 and TXK.

Uniprot	P09874
Gene Name	PARP1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:142
Unigene	Hs.177766

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SKU	Supplier No.	Size	Your price	Quantity
BHE13808441	E0947h	96T	$736		Add to Cart

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