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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Poliovirus receptor

SKU : BHE13809392

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15367h
Alternative Names	Nectin-like protein 5 ; NECL-5 ; CD155 ; PVS
Categories	Elisa
Function	Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.
Specificity	Natural and recombinant Human Poliovirus receptor
Subcellular Location	Isoform Gamma Secreted
Entryname	PVR_HUMAN
Platform	PF08205
Protein Name	Poliovirus receptor
Sequence	50: MARAMAAAWP ; LLLVALLVLS ; WPPPGTGDVV ; VQAPTQVPGF ; LGDSVTLPCY ; 100: LQVPNMEVTH ; VSQLTWARHG ; ESGSMAVFHQ ; TQGPSYSESK ; RLEFVAARLG ; 150: AELRNASLRM ; FGLRVEDEGN ; YTCLFVTFPQ ; GSRSVDIWLR ; VLAKPQNTAE ; 200: VQKVQLTGEP ; VPMARCVSTG ; GRPPAQITWH ; SDLGGMPNTS ; QVPGFLSGTV ; 250: TVTSLWILVP ; SSQVDGKNVT ; CKVEHESFEK ; PQLLTVNLTV ; YYPPEVSISG ; 300: YDNNWYLGQN ; EATLTCDARS ; NPEPTGYNWS ; TTMGPLPPFA ; VAQGAQLLIR ; 350: PVDKPINTTL ; ICNVTNALGA ; RQAELTVQVK ; EGPPSEHSGI ; SRNAIIFLVL ; 400: GILVFLILLG ; IGIYFYWSKC ; SREVLWHCHL ; CPSSTEHASA ; SANGHVSYSA ; 417: VSRENSSSQD ; PQTEGTR
Sequence Length	417
String	P15151
Sub Unit	Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT.

Uniprot	P15151
Gene Name	PVR
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5817
Unigene	Hs.171844

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809392	E15367h	96T	$736		Add to Cart

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