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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Pleckstrin homology domain-containing family O member 1

SKU : BHE13809443

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15005h
Alternative Names	C-Jun-binding protein ; JBP ; Casein kinase 2-interacting protein 1 ; CK2-interacting protein 1 ; Osteoclast maturation-associated gene 120 protein ; CKIP1 ; OC120 ; HQ0024c
Categories	Elisa
Function	Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.
Specificity	Natural and recombinant Human Pleckstrin homology domain-containing family O member 1
Subcellular Location	Cell membrane Nucleus Cytoplasm Predominantly localized to the plasma membrane. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells.
Detection Range	0.625-40ng/ml
Entryname	PKHO1_HUMAN
Method Type	Competitive
Platform	PF00169
Protein Name	Pleckstrin homology domain-containing family O member 1
Sensitivity	0.21ng/ml
Sequence	50: MMKKNNSAKR ; GPQDGNQQPA ; PPEKVGWVRK ; FCGKGIFREI ; WKNRYVVLKG ; 100: DQLYISEKEV ; KDEKNIQEVF ; DLSDYEKCEE ; LRKSKSRSKK ; NHSKFTLAHS ; 150: KQPGNTAPNL ; IFLAVSPEEK ; ESWINALNSA ; ITRAKNRILD ; EVTVEEDSYL ; 200: AHPTRDRAKI ; QHSRRPPTRG ; HLMAVASTST ; SDGMLTLDLI ; QEEDPSPEEP ; 250: TSCAESFRVD ; LDKSVAQLAG ; SRRRADSDRI ; QPSADRASSL ; SRPWEKTDKG ; 300: ATYTPQAPKK ; LTPTEKGRCA ; SLEEILSQRD ; AASARTLQLR ; AEEPPTPALP ; 350: NPGQLSRIQD ; LVARKLEETQ ; ELLAEVQGLG ; DGKRKAKDPP ; RSPPDSESEQ ; 400: LLLETERLLG ; EASSNWSQAK ; RVLQEVRELR ; DLYRQMDLQT ; PDSHLRQTTP ; 409: HSQYRKSLM
Sequence Length	409
String	Q53GL0
Sub Unit	Heterodimer or homodimer. Interacts with CK2 and actin capping subunits (capping protein CP-alpha and CP-beta). CKIP1 and CK2 together inhibit the activity of actin capping protein at the barbed ends of actin filaments. Interacts with ATM, IFP35, JUN, JUND, NMI and PI3K. Interacts with AKT1, AKT2 and AKT3 (each isozyme of PKB), PtdIns(3,5)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P2.

Uniprot	Q53GL0
Gene Name	PLEKHO1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51177
Unigene	Hs.438824

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809443	E15005h	96T	$736		Add to Cart

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