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ELISA Kit for Human Platelet glycoprotein IX

SKU : BHE13805487

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1904h
Alternative Names	Glycoprotein 9 ; CD42a
Categories	Elisa
Function	The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.
Specificity	Natural and recombinant Human Platelet glycoprotein IX
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	15.6-1000pg/mL
Entryname	GPIX_HUMAN
Method Type	Sandwich
Platform	PF01462
Protein Name	Platelet glycoprotein IX
Sensitivity	5.6pg/mL
Sequence	50: MPAWGALFLL ; WATAEATKDC ; PSPCTCRALE ; TMGLWVDCRG ; HGLTALPALP ; 100: ARTRHLLLAN ; NSLQSVPPGA ; FDHLPQLQTL ; DVTQNPWHCD ; CSLTYLRLWL ; 150: EDRTPEALLQ ; VRCASPSLAA ; HGPLGRLTGY ; QLGSCGWQLQ ; ASWVRPGVLW ; 177: DVALVAVAAL ; GLALLAGLLC ; ATTEALD
Sequence Length	177
String	P14770
Sub Unit	GP-Ib alpha and beta are disulfide linked. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage.

Uniprot	P14770
Gene Name	GP9
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:2815
Unigene	Hs.1144

Reference	1. "Human platelet glycoprotein IX. Characterization of cDNA and localization of the gene to chromosome 3." Hickey M.J., Deaven L.L., Roth G.J. FEBS Lett.274:189-192(1990) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 17-33 AND 98-109 2. Roth G.J. Submitted (1997-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 125 3. "Characterization of the gene encoding human platelet glycoprotein IX." Hickey M.J., Roth G.J. J. Biol. Chem.268:3438-3443(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] tissue: Liver. 4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT THR-156 tissue: Pancreas. 5. "Human platelet glycoprotein IX: an adhesive prototype of leucine-rich glycoproteins with flank-center-flank structures." Hickey M.J., Williams S.A., Roth G.J. Proc. Natl. Acad. Sci. U.S.A.86:6773-6777(1989) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 12-177;PROTEIN SEQUENCE OF 17-33 AND 98-109 6. "Corrected DNA sequence of the platelet glycoprotein IX gene." Hayashi T., Suzuki K. Thromb. Haemost.77:1034-1035(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-141 7. "Isolation and characterization of human platelet glycoprotein IX." Roth G.J., Ozols J., Nugent D.J., Williams S.A. Biochem. Biophys. Res. Commun.156:931-939(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-33 8. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-27 tissue: Platelet. 9. "Double heterozygosity for mutations in the platelet glycoprotein IX gene in three siblings with Bernard-Soulier syndrome." Wright S.D., Michaelides K., Johnson D.J., West N.C., Tuddenham E.G. Blood81:2339-2347(1993) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BSS GLY-37 AND SER-61 10. "A phenylalanine-55 to serine amino-acid substitution in the human glycoprotein IX leucine-rich repeat is associated with Bernard-Soulier syndrome." Noris P., Simsek S., Stibbe J., von dem Borne A.E.G.K. Br. J. Haematol.97:312-320(1997) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS SER-71 11. "A new variant of Bernard-Soulier syndrome characterized by dysfunctional glycoprotein (GP) Ib and severely reduced amounts of GPIX and GPV." Noris P., Arbustini E., Spedini P., Belletti S., Balduini C.L. Br. J. Haematol.103:1004-1013(1998) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS PRO-56 12. "Cys97-->Tyr mutation in the glycoprotein IX gene associated with Bernard-Soulier syndrome." Kunishima S., Tomiyama Y., Honda S., Kurata Y., Kamiya T., Ozawa K., Saito H. Br. J. Haematol.107:539-545(1999) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS TYR-113 13. "Identification of a new mutation in platelet glycoprotein IX (GPIX) in a patient with Bernard-Soulier syndrome." Rivera C.E., Villagra J., Riordan M., Williams S., Lindstrom K.J., Rick M.E. Br. J. Haematol.112:105-108(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS ARG-24 14. "A novel point mutation in the transmembrane domain of platelet glycoprotein IX gene identified in a Bernard-Soulier syndrome patient." Wang Z., Shi J., Han Y. Zhonghua Xue Ye Xue Za Zhi22:464-466(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS THR-156 15. "A Leu7-to-Pro mutation in the signal peptide of platelet glycoprotein (GP)IX in a case of Bernard-Soulier syndrome abolishes surface expression of the GPIb-V-IX complex." Lanza F., de la Salle C., Baas M.-J., Schwartz A., Boval B., Cazenave J.-P., Caen J.P. Br. J. Haematol.118:260-266(2002) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS PRO-7

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