Clathrin assembly lymphoid myeloid leukemia protein ; CALM
Categories
Elisa
Function
Assembly protein recruiting clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction.
Specificity
Natural and recombinant Human Phosphatidylinositol-binding clathrin assembly protein
Subcellular Location
Membrane clathrin-coated pit Golgi apparatus Cytoplasmic vesicle clathrin-coated vesicle Colocalized with clathrin in the Golgi area.
Binds clathrin; involves primarily the C-terminal sequences, but the full-length protein is required for full binding capacity. Binds phosphatidylinositol-4,5- bisphosphate.