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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

SKU : BHE13809124

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14309h
Alternative Names	Phosphatidylinositol 4 ; 5-bisphosphate 3-kinase 110 kDa catalytic subunit delta ; PtdIns-3-kinase subunit p110-delta
Categories	Elisa
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Mediates immune responses. Plays a role in B-cell development, proliferation, migration, and function. Required for B-cell receptor (BCR) signaling. Mediates B-cell proliferation response to anti-IgM, anti-CD40 and IL4 stimulation. Promotes cytokine production in response to TLR4 and TLR9. Required for antibody class switch mediated by TLR9. Involved in the antigen presentation function of B-cells. Involved in B-cell chemotaxis in response to CXCL13 and sphingosine 1-phosphate (S1P). Required for proliferation, signaling and cytokine production of naive, effector and memory T-cells. Required for T-cell receptor (TCR) signaling. Mediates TCR signaling events at the immune synapse. Activation by TCR leads to antigen-dependent memory T-cell migration and retention to antigenic tissues. Together with PIK3CG participates in T-cell development. Contributes to T helper cell expansion and differentiation. Required for T-cell migration mediated by homing receptors SELL/CD62L, CCR7 and S1PR1 and antigen dependent recruitment of T-cells. Together with PIK3CG is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in NK cell receptor activation. Have a role in NK cell maturation and cytokine production. Together with PIK3CG is involved in neutrophil chemotaxis and extravasation. Together with PIK3CG participates in neutrophil respiratory burst. Have important roles in mast-cell development and mast cell mediated allergic response. Involved in stem cell factor (SCF)-mediated proliferation, adhesion and migration. Required for allergen-IgE-induced degranulation and cytokine release. The lipid kinase activity is required for its biological function.
Specificity	Natural and recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Detection Range	0.312-20ng/mL
Entryname	PK3CD_HUMAN
Method Type	Sandwich
Platform	PF00454
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Sensitivity	0.089 ng/ml
Sequence	50: MPPGVDCPME ; FWTKEENQSV ; VVDFLLPTGV ; YLNFPVSRNA ; NLSTIKQLLW ; 100: HRAQYEPLFH ; MLSGPEAYVF ; TCINQTAEQQ ; ELEDEQRRLC ; DVQPFLPVLR ; 150: LVAREGDRVK ; KLINSQISLL ; IGKGLHEFDS ; LCDPEVNDFR ; AKMCQFCEEA ; 200: AARRQQLGWE ; AWLQYSFPLQ ; LEPSAQTWGP ; GTLRLPNRAL ; LVNVKFEGSE ; 250: ESFTFQVSTK ; DVPLALMACA ; LRKKATVFRQ ; PLVEQPEDYT ; LQVNGRHEYL ; 300: YGSYPLCQFQ ; YICSCLHSGL ; TPHLTMVHSS ; SILAMRDEQS ; NPAPQVQKPR ; 350: AKPPPIPAKK ; PSSVSLWSLE ; QPFRIELIQG ; SKVNADERMK ; LVVQAGLFHG ; 400: NEMLCKTVSS ; SEVSVCSEPV ; WKQRLEFDIN ; ICDLPRMARL ; CFALYAVIEK ; 450: AKKARSTKKK ; SKKADCPIAW ; ANLMLFDYKD ; QLKTGERCLY ; MWPSVPDEKG ; 500: ELLNPTGTVR ; SNPNTDSAAA ; LLICLPEVAP ; HPVYYPALEK ; ILELGRHSEC ; 550: VHVTEEEQLQ ; LREILERRGS ; GELYEHEKDL ; VWKLRHEVQE ; HFPEALARLL ; 600: LVTKWNKHED ; VAQMLYLLCS ; WPELPVLSAL ; ELLDFSFPDC ; HVGSFAIKSL ; 650: RKLTDDELFQ ; YLLQLVQVLK ; YESYLDCELT ; KFLLDRALAN ; RKIGHFLFWH ; 700: LRSEMHVPSV ; ALRFGLILEA ; YCRGSTHHMK ; VLMKQGEALS ; KLKALNDFVK ; 750: LSSQKTPKPQ ; TKELMHLCMR ; QEAYLEALSH ; LQSPLDPSTL ; LAEVCVEQCT ; 800: FMDSKMKPLW ; IMYSNEEAGS ; GGSVGIIFKN ; GDDLRQDMLT ; LQMIQLMDVL ; 850: WKQEGLDLRM ; TPYGCLPTGD ; RTGLIEVVLR ; SDTIANIQLN ; KSNMAATAAF ; 900: NKDALLNWLK ; SKNPGEALDR ; AIEEFTLSCA ; GYCVATYVLG ; IGDRHSDNIM ; 950: IRESGQLFHI ; DFGHFLGNFK ; TKFGINRERV ; PFILTYDFVH ; VIQQGKTNNS ; 1000: EKFERFRGYC ; ERAYTILRRH ; GLLFLHLFAL ; MRAAGLPELS ; CSKDIQYLKD ; 1044: SLALGKTEEE ; ALKHFRVKFN ; EALRESWKTK ; VNWLAHNVSK ; DNRQ
Sequence Length	1044
String	O00329
Sub Unit	Heterodimer of a catalytic subunit PIK3CD and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with ERAS.

Uniprot	O00329
Gene Name	PIK3CD
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5293
Unigene	Hs.518451

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809124	E14309h	96T	$736		Add to Cart

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