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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

SKU : BHE13809294

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14307h
Alternative Names	Phosphatidylinositol 4 ; 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha ; PtdIns-3-kinase subunit p110-alpha ; Phosphoinositide-3-kinase catalytic alpha polypeptide ; Serine/threonine protein kinase PIK3CA ; 2.7.11.1
Categories	Elisa
Function	Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol-3,4,5-triphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.
Specificity	Natural and recombinant Human Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Detection Range	0.156-10ng/mL
Entryname	PK3CA_HUMAN
Method Type	Sandwich
Platform	PF00454
Protein Name	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Sensitivity	0.056ng/ml
Sequence	50: MPPRPSSGEL ; WGIHLMPPRI ; LVECLLPNGM ; IVTLECLREA ; TLITIKHELF ; 100: KEARKYPLHQ ; LLQDESSYIF ; VSVTQEAERE ; EFFDETRRLC ; DLRLFQPFLK ; 150: VIEPVGNREE ; KILNREIGFA ; IGMPVCEFDM ; VKDPEVQDFR ; RNILNVCKEA ; 200: VDLRDLNSPH ; SRAMYVYPPN ; VESSPELPKH ; IYNKLDKGQI ; IVVIWVIVSP ; 250: NNDKQKYTLK ; INHDCVPEQV ; IAEAIRKKTR ; SMLLSSEQLK ; LCVLEYQGKY ; 300: ILKVCGCDEY ; FLEKYPLSQY ; KYIRSCIMLG ; RMPNLMLMAK ; ESLYSQLPMD ; 350: CFTMPSYSRR ; ISTATPYMNG ; ETSTKSLWVI ; NSALRIKILC ; ATYVNVNIRD ; 400: IDKIYVRTGI ; YHGGEPLCDN ; VNTQRVPCSN ; PRWNEWLNYD ; IYIPDLPRAA ; 450: RLCLSICSVK ; GRKGAKEEHC ; PLAWGNINLF ; DYTDTLVSGK ; MALNLWPVPH ; 500: GLEDLLNPIG ; VTGSNPNKET ; PCLELEFDWF ; SSVVKFPDMS ; VIEEHANWSV ; 550: SREAGFSYSH ; AGLSNRLARD ; NELRENDKEQ ; LKAISTRDPL ; SEITEQEKDF ; 600: LWSHRHYCVT ; IPEILPKLLL ; SVKWNSRDEV ; AQMYCLVKDW ; PPIKPEQAME ; 650: LLDCNYPDPM ; VRGFAVRCLE ; KYLTDDKLSQ ; YLIQLVQVLK ; YEQYLDNLLV ; 700: RFLLKKALTN ; QRIGHFFFWH ; LKSEMHNKTV ; SQRFGLLLES ; YCRACGMYLK ; 750: HLNRQVEAME ; KLINLTDILK ; QEKKDETQKV ; QMKFLVEQMR ; RPDFMDALQG ; 800: FLSPLNPAHQ ; LGNLRLEECR ; IMSSAKRPLW ; LNWENPDIMS ; ELLFQNNEII ; 850: FKNGDDLRQD ; MLTLQIIRIM ; ENIWQNQGLD ; LRMLPYGCLS ; IGDCVGLIEV ; 900: VRNSHTIMQI ; QCKGGLKGAL ; QFNSHTLHQW ; LKDKNKGEIY ; DAAIDLFTRS ; 950: CAGYCVATFI ; LGIGDRHNSN ; IMVKDDGQLF ; HIDFGHFLDH ; KKKKFGYKRE ; 1000: RVPFVLTQDF ; LIVISKGAQE ; CTKTREFERF ; QEMCYKAYLA ; IRQHANLFIN ; 1050: LFSMMLGSGM ; PELQSFDDIA ; YIRKTLALDK ; TEQEALEYFM ; KQMNDAHHGG ; 1068: WTTKMDWIFH ; TIKQHALN
Sequence Length	1068
String	P42336
Sub Unit	Heterodimer of a catalytic subunit PIK3CA and a p85 regulatory subunit (PIK3R1, PIK3R2 or PIK3R3). Interacts with IRS1 in nuclear extracts. Interacts with RUFY3 (By similarity). Interacts with RASD2 (By similarity). Interacts with APPL1. Interacts with HRAS1 and KRAS (By similarity). Interaction with HRAS1/KRAS is required for PI3K pathway signaling and cell proliferation stimulated by EGF and FGF2.

Uniprot	P42336
Gene Name	PIK3CA
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:5290
Unigene	Hs.553498

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SKU	Supplier No.	Size	Your price	Quantity
BHE13809294	E14307h	96T	$736		Add to Cart

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