Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Specificity
Natural and recombinant Human Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
Subcellular Location
Cytoplasm cytosol Cell membrane Mainly cytosolic. Some amount is apparently associated to the plasma membrane.