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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

SKU : BHE13810567

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E8909h
Alternative Names	Inositol polyphosphate-5-phosphatase of 145 kDa ; SIP-145 ; SH2 domain-containing inositol 5'-phosphatase 1 ; SH2 domain-containing inositol phosphatase 1 ; p150Ship ; hp51CN ; SHIP ; SHIP1
Categories	Elisa
Function	Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6.
Specificity	Natural and recombinant Human Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Subcellular Location	Cytoplasm Membrane Peripheral membrane protein Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate to membrane localization.
Detection Range	0.312-20ng/ml
Entryname	SHIP1_HUMAN
Method Type	Competitive
Platform	PF03372
Protein Name	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
Sensitivity	0.15ng/mL
Sequence	50: MVPCWNHGNI ; TRSKAEELLS ; RTGKDGSFLV ; RASESISRAY ; ALCVLYRNCV ; 100: YTYRILPNED ; DKFTVQASEG ; VSMRFFTKLD ; QLIEFYKKEN ; MGLVTHLQYP ; 150: VPLEEEDTGD ; DPEEDTVESV ; VSPPELPPRN ; IPLTASSCEA ; KEVPFSNENP ; 200: RATETSRPSL ; SETLFQRLQS ; MDTSGLPEEH ; LKAIQDYLST ; QLAQDSEFVK ; 250: TGSSSLPHLK ; KLTTLLCKEL ; YGEVIRTLPS ; LESLQRLFDQ ; QLSPGLRPRP ; 300: QVPGEANPIN ; MVSKLSQLTS ; LLSSIEDKVK ; ALLHEGPESP ; HRPSLIPPVT ; 350: FEVKAESLGI ; PQKMQLKVDV ; ESGKLIIKKS ; KDGSEDKFYS ; HKKILQLIKS ; 400: QKFLNKLVIL ; VETEKEKILR ; KEYVFADSKK ; REGFCQLLQQ ; MKNKHSEQPE ; 450: PDMITIFIGT ; WNMGNAPPPK ; KITSWFLSKG ; QGKTRDDSAD ; YIPHDIYVIG ; 500: TQEDPLSEKE ; WLEILKHSLQ ; EITSVTFKTV ; AIHTLWNIRI ; VVLAKPEHEN ; 550: RISHICTDNV ; KTGIANTLGN ; KGAVGVSFMF ; NGTSLGFVNS ; HLTSGSEKKL ; 600: RRNQNYMNIL ; RFLALGDKKL ; SPFNITHRFT ; HLFWFGDLNY ; RVDLPTWEAE ; 650: TIIQKIKQQQ ; YADLLSHDQL ; LTERREQKVF ; LHFEEEEITF ; APTYRFERLT ; 700: RDKYAYTKQK ; ATGMKYNLPS ; WCDRVLWKSY ; PLVHVVCQSY ; GSTSDIMTSD ; 750: HSPVFATFEA ; GVTSQFVSKN ; GPGTVDSQGQ ; IEFLRCYATL ; KTKSQTKFYL ; 800: EFHSSCLESF ; VKSQEGENEE ; GSEGELVVKF ; GETLPKLKPI ; ISDPEYLLDQ ; 850: HILISIKSSD ; SDESYGEGCI ; ALRLEATETQ ; LPIYTPLTHH ; GELTGHFQGE ; 900: IKLQTSQGKT ; REKLYDFVKT ; ERDESSGPKT ; LKSLTSHDPM ; KQWEVTSRAP ; 950: PCSGSSITEI ; INPNYMGVGP ; FGPPMPLHVK ; QTLSPDQQPT ; AWSYDQPPKD ; 1000: SPLGPCRGES ; PPTPPGQPPI ; SPKKFLPSTA ; NRGLPPRTQE ; SRPSDLGKNA ; 1050: GDTLPQEDLP ; LTKPEMFENP ; LYGSLSSFPK ; PAPRKDQESP ; KMPRKEPPPC ; 1100: PEPGILSPSI ; VLTKAQEADR ; GEGPGKQVPA ; PRLRSFTCSS ; SAEGRAAGGD ; 1150: KSQGKPKTPV ; SSQAPVPAKR ; PIKPSRSEIN ; QQTPPTPTPR ; PPLPVKSPAV ; 1189: LHLQHSKGRD ; YRDNTELPHH ; GKHRPEEGPP ; GPLGRTAMQ
Sequence Length	1189
String	Q92835
Sub Unit	Interacts with tyrosine phosphorylated forms of SHC1, DOK1, DOK3, PTPN11/SHP-2, SLAMF1/CD150. Interacts with PTPN11 in response to IL-3. Interacts with receptors EPOR, MS4A2/FCER1B and FCER1G, FCGR2A, FCGR2B and FCGR3. Interacts with GRB2 and PLCG1. Interacts with tyrosine kinases SRC and TEC. Interacts with FCGR2A, leading to regulate gene expression during the phagocytic process. Interacts with c-Met/MET (By similarity). Interacts with MILR1 (tyrosine-phosphorylated).

Uniprot	Q92835
Gene Name	INPP5D
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3635
Unigene	Hs.262886

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810567	E8909h	96T	$736		Add to Cart

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