PTH/PTHrP type I receptor ; PTH/PTHr receptor ; Parathyroid hormone 1 receptor ; PTH1 receptor ; PTHR ; PTHR1
Categories
Elisa
Function
This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Specificity
Natural and recombinant Human Parathyroid hormone/parathyroid hormone-related peptide receptor
Interacts (via N-terminal extracellular domain) with PTHLH and PTH. Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer. Interacts (via C-terminus) with the heterodimer formed by GNG2 and GNB1.