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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Nuclear factor NF-kappa-B p105 subunit

SKU : BHE13806765

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1824h
Alternative Names	DNA-binding factor KBF1 ; EBP-1 ; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
Categories	Elisa
Function	NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally. p50 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. In a complex with MAP3K8, NFKB1/p105 represses MAP3K8-induced MAPK signaling; active MAP3K8 is released by proteasome-dependent degradation of NFKB1/p105.
Specificity	Natural and recombinant Human Nuclear factor NF-kappa-B p105 subunit
Subcellular Location	Nucleus Cytoplasm Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
Detection Range	0.312-20ng/mL
Entryname	NFKB1_HUMAN
Method Type	Sandwich
Platform	PF00023
Protein Name	Nuclear factor NF-kappa-B p105 subunit
Sensitivity	0.23ng/mL
Sequence	50: MAEDDPYLGR ; PEQMFHLDPS ; LTHTIFNPEV ; FQPQMALPTD ; GPYLQILEQP ; 100: KQRGFRFRYV ; CEGPSHGGLP ; GASSEKNKKS ; YPQVKICNYV ; GPAKVIVQLV ; 150: TNGKNIHLHA ; HSLVGKHCED ; GICTVTAGPK ; DMVVGFANLG ; ILHVTKKKVF ; 200: ETLEARMTEA ; CIRGYNPGLL ; VHPDLAYLQA ; EGGGDRQLGD ; REKELIRQAA ; 250: LQQTKEMDLS ; VVRLMFTAFL ; PDSTGSFTRR ; LEPVVSDAIY ; DSKAPNASNL ; 300: KIVRMDRTAG ; CVTGGEEIYL ; LCDKVQKDDI ; QIRFYEEEEN ; GGVWEGFGDF ; 350: SPTDVHRQFA ; IVFKTPKYKD ; INITKPASVF ; VQLRRKSDLE ; TSEPKPFLYY ; 400: PEIKDKEEVQ ; RKRQKLMPNF ; SDSFGGGSGA ; GAGGGGMFGS ; GGGGGGTGST ; 450: GPGYSFPHYG ; FPTYGGITFH ; PGTTKSNAGM ; KHGTMDTESK ; KDPEGCDKSD ; 500: DKNTVNLFGK ; VIETTEQDQE ; PSEATVGNGE ; VTLTYATGTK ; EESAGVQDNL ; 550: FLEKAMQLAK ; RHANALFDYA ; VTGDVKMLLA ; VQRHLTAVQD ; ENGDSVLHLA ; 600: IIHLHSQLVR ; DLLEVTSGLI ; SDDIINMRND ; LYQTPLHLAV ; ITKQEDVVED ; 650: LLRAGADLSL ; LDRLGNSVLH ; LAAKEGHDKV ; LSILLKHKKA ; ALLLDHPNGD ; 700: GLNAIHLAMM ; SNSLPCLLLL ; VAAGADVNAQ ; EQKSGRTALH ; LAVEHDNISL ; 750: AGCLLLEGDA ; HVDSTTYDGT ; TPLHIAAGRG ; STRLAALLKA ; AGADPLVENF ; 800: EPLYDLDDSW ; ENAGEDEGVV ; PGTTPLDMAT ; SWQVFDILNG ; KPYEPEFTSD ; 850: DLLAQGDMKQ ; LAEDVKLQLY ; KLLEIPDPDK ; NWATLAQKLG ; LGILNNAFRL ; 900: SPAPSKTLMD ; NYEVSGGTVR ; ELVEALRQMG ; YTEAIEVIQA ; ASSPVKTTSQ ; 950: AHSLPLSPAS ; TRQQIDELRD ; SDSVCDSGVE ; TSFRKLSFTE ; SLTSGASLLT ; 968: LNKMPHDYGQ ; EGPLEGKI
Sequence Length	968
String	P19838
Sub Unit	Component of the NF-kappa-B p65-p50 complex. Component of the NF-kappa-B p65-p50 complex. Homodimer; component of the NF-kappa-B p50-p50 complex. Component of the NF-kappa-B p105-p50 complex. Component of the NF-kappa-B p50-c-Rel complex. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Also interacts with MAP3K8. NF-kappa-B p50 subunit interacts with NCOA3 coactivator, which may coactivate NF-kappa-B dependent expression via its histone acetyltransferase activity. Interacts with DSIPI; this interaction prevents nuclear translocation and DNA-binding. Interacts with SPAG9 and UNC5CL. NFKB1/p105 interacts with CFLAR; the interaction inhibits p105 processing into p50. NFKB1/p105 forms a ternary complex with MAP3K8 and TNIP2. Interacts with GSK3B; the interaction prevents processing of p105 to p50. NFKB1/p50 interacts with NFKBIE. NFKB1/p50 interacts with NFKBIZ. Nuclear factor NF-kappa-B p50 subunit interacts with NFKBID (By similarity). Directly interacts with MEN1.

Uniprot	P19838
Gene Name	NFKB1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4790
Unigene	Hs.618430

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806765	E1824h	96T	$736		Add to Cart

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