Axonal membrane protein GAP-43 ; Growth-associated protein 43 ; Neural phosphoprotein B-50 ; pp46
Categories
Elisa
Function
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
Specificity
Natural and recombinant Human Neuromodulin
Subcellular Location
Cell membrane Peripheral membrane protein Cytoplasmic side Cell projection growth cone membrane Peripheral membrane protein Cytoplasmic side Cell junction synapse Cell projection filopodium membrane Peripheral membrane protein Cytoplasmic surface of growth cone and synaptic plasma membranes.
Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2A, SRC, SHC1, GAP43 and CTTN (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.