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ELISA Kit for Human Neuroendocrine protein 7B2

SKU : BHE13800425

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9861h
Alternative Names	Pituitary polypeptide ; Secretogranin V ; Secretogranin-5 ; Secretory granule endocrine protein I ; SGNE1
Categories	Elisa
Function	Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
Specificity	Natural and recombinant Human Neuroendocrine protein 7B2
Subcellular Location	Secreted Neuroendocrine and endocrine secretory granules.
Detection Range	31.2-2000pg/mL
Entryname	7B2_HUMAN
Method Type	Sandwich
Platform	PF05281
Protein Name	Neuroendocrine protein 7B2
Sensitivity	16pg/mL
Sequence	50: MVSRMVSTML ; SGLLFWLASG ; WTPAFAYSPR ; TPDRVSEADI ; QRLLHGVMEQ ; 100: LGIARPRVEY ; PAHQAMNLVG ; PQSIEGGAHE ; GLQHLGPFGN ; IPNIVAELTG ; 150: DNIPKDFSED ; QGYPDPPNPC ; PVGKTADDGC ; LENTPDTAEF ; SREFQLHQHL ; 200: FDPEHDYPGL ; GKWNKKLLYE ; KMKGGERRKR ; RSVNPYLQGQ ; RLDNVVAKKS ; 212: VPHFSDEDKD ; PE
Sequence Length	212
String	P05408
Sub Unit	Interacts with PCSK2/PC2 early in the secretory pathway. Dissociation occurs at later stages.

Uniprot	P05408
Gene Name	SCG5
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6447
Unigene	Hs.156540

Reference	1. "Cloning and sequence analysis of human pituitary cDNA encoding the novel polypeptide 7B2." Martens G.J.M. FEBS Lett.234:160-164(1988) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2) tissue: Pituitary. 2. "The production by alteate splicing of two mRNAs differing by one codon could be an intrinsic property of neuroendocrine protein 7B2 gene expression in man." Paquet L., Lazure C., Seidah N.G., Chretien M., Mbikay M. Biochem. Biophys. Res. Commun.174:156-162(1991) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PROTEIN SEQUENCE OF 125-140 (ISOFORM 1);PROTEIN SEQUENCE OF 126-132 (ISOFORM 2) tissue: Pituitary. 3. "Human neuroendocrine protein 7B2 genomic organization." Jackson R.S. Submitted (2000-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] 4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Ko B. Submitted (2004-06) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) 5. Mural R.J., Istrail S., Sutton G., Florea L., Halpe A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Tuer R., Yooseph S., Lu F., Nusske D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.more... Submitted (2005-07) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2) tissue: Pancreas. 7. "Structural organization of the gene encoding the neuroendocrine chaperone 7B2." Braks J.A., Broers C.A., Danger J.M., Martens G.J.M. Eur. J. Biochem.236:60-67(1996) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 61-92 8. "Isolation and NH2-terminal sequence of a highly conserved human and porcine pituitary protein belonging to a new superfamily. Immunocytochemical localization in pars distalis and pars nervosa of the pituitary and in the supraoptic nucleus of the hypothalamus." Seidah N.G., Hsi K.L., de Serres G., Rochemont J., Hamelin J., Antakly T., Cantin M., Chretien M. Arch. Biochem. Biophys.225:525-534(1983) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-103 9. "7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway." Braks J.A., Martens G.J.M. Cell78:263-273(1994) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PCSK2 10. "Neuroendocrine secretory protein 7B2: structure, expression and functions." Mbikay M., Seidah N.G., Chretien M. Biochem. J.357:329-342(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW

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