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ELISA Kit for Human Neurabin-2

SKU : BHE13808390

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E8951h
Alternative Names	Neurabin-II ; Protein phosphatase 1 regulatory subunit 9B ; Spinophilin ; PPP1R6
Categories	Elisa
Function	Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1 (By similarity). Required for hepatocyte growth factor (HGF)-induced cell migration.
Specificity	Natural and recombinant Human Neurabin-2
Subcellular Location	Cytoplasm cytoskeleton Nucleus Cell projection dendritic spine Cell junction synapse Cell junction adherens junction Cytoplasm Cell membrane Cell projection lamellipodium Cell projection filopodium Cell projection ruffle membrane Enriched at synapse and cadherin-based cell-cell adhesion sites. In neurons, both cytosolic and membrane-associated, and highly enriched in the post-synaptic density apposed to exitatory synapses. Colocalizes with PPP1R2 at actin-rich adherens junctions in epithelial cells and in dendritic spines (By similarity). Accumulates in the lamellipodium, filopodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
Detection Range	0.156-10ng/mL
Entryname	NEB2_HUMAN
Method Type	Sandwich
Platform	PF00595
Protein Name	Neurabin-2
Sensitivity	0.098ng/mL
Sequence	50: MMKTEPRGPG ; GPLRSASPHR ; SAYEAGIQAL ; KPPDAPGPDE ; APKGAHHKKY ; 100: GSNVHRIKSM ; FLQMGTTAGP ; SGEAGGGAGL ; AEAPRASERG ; VRLSLPRASS ; 150: LNENVDHSAL ; LKLGTSVSER ; VSRFDSKPAP ; SAQPAPPPHP ; PSRLQETRKL ; 200: FERSAPAAGG ; DKEAARRLLR ; QERAGLQDRK ; LDVVVRFNGS ; TEALDKLDAD ; 250: AVSPTVSQLS ; AVFEKADSRT ; GLHRGPGLPR ; AAGVPQVNSK ; LVSKRSRVFQ ; 300: PPPPPPPAPS ; GDAPAEKERC ; PAGQQPPQHR ; VAPARPPPKP ; REVRKIKPVE ; 350: VEESGESEAE ; SAPGEVIQAE ; VTVHAALENG ; STVATAASPA ; PEEPKAQAAP ; 400: EKEAAAVAPP ; ERGVGNGRAP ; DVAPEEVDES ; KKEDFSEADL ; VDVSAYSGLG ; 450: EDSAGSALEE ; DDEDDEEDGE ; PPYEPESGCV ; EIPGLSEEED ; PAPSRKIHFS ; 500: TAPIQVFSTY ; SNEDYDRRNE ; DVDPMAASAE ; YELEKRVERL ; ELFPVELEKD ; 550: SEGLGISIIG ; MGAGADMGLE ; KLGIFVKTVT ; EGGAAHRDGR ; IQVNDLLVEV ; 600: DGTSLVGVTQ ; SFAASVLRNT ; KGRVRFMIGR ; ERPGEQSEVA ; QLIQQTLEQE ; 650: RWQREMMEQR ; YAQYGEDDEE ; TGEYATDEDE ; ELSPTFPGGE ; MAIEVFELAE ; 700: NEDALSPVDM ; EPEKLVHKFK ; ELQIKHAVTE ; AEIQQLKRKL ; QSLEQEKGRW ; 750: RVEKAQLEQS ; VEENKERMEK ; LEGYWGEAQS ; LCQAVDEHLR ; ETQAQYQALE ; 800: RKYSKAKRLI ; KDYQQKEIEF ; LKKETAQRRV ; LEESELARKE ; EMDKLLDKIS ; 815: ELEGNLQTLR ; NSNST
Sequence Length	815
String	Q96SB3
Sub Unit	Possibly exists as an homodimer, homotrimer or an homotetramer. Interacts with F-actin, PPP1CA, neurabin-1, TGN38 and D(2) dopamine receptor. Interacts with RGS1, RGS2, RGS4, RGS19 and ADRA1B, ADRA2A, ADRA2B, ADRA2C, CDKN2A, PPP1R2, RASGFR1 and TIAM1. Interacts (via C-terminus) with SPATA13 (via C-terminal tail).

Uniprot	Q96SB3
Gene Name	PPP1R9B
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:84687
Unigene	Hs.514323

Reference	1. "The human tumor suppressor ARF interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein." Vivo M., Calogero R.A., Sansone F., Calabro V., Parisi T., Borrelli L., Saviozzi S., La Mantia G. J. Biol. Chem.276:14161-14169(2001) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;INTERACTION WITH CDKN2A 2. "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.more... BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 396-815 tissue: Amygdala. 3. "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 5. "Asef2 and Neurabin2 cooperatively regulate actin cytoskeletal organization and are involved in HGF-induced cell migration." Sagara M., Kawasaki Y., Iemura S.I., Natsume T., Takai Y., Akiyama T. Oncogene28:1357-1365(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH SPATA13 6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Leukemic T-cell. 7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-203;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] tissue: Cervix carcinoma. 8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-190;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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