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Home / Assay Kits / ELISA Kits

ELISA Kit for Human NEDD8-activating enzyme E1 catalytic subunit

SKU : BHE13811522

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1027h
Alternative Names	NEDD8-activating enzyme E1C ; Ubiquitin-activating enzyme E1C ; Ubiquitin-like modifier-activating enzyme 3 ; Ubiquitin-activating enzyme 3 ; UBE1C
Categories	Elisa
Function	Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
Specificity	Natural and recombinant Human NEDD8-activating enzyme E1 catalytic subunit
Detection Range	0.156-10ng/mL
Entryname	UBA3_HUMAN
Method Type	Sandwich
Platform	PF08825
Protein Name	NEDD8-activating enzyme E1 catalytic subunit
Sensitivity	0.081ng/mL
Sequence	50: MADGEEPEKK ; RRRIEELLAE ; KMAVDGGCGD ; TGDWEGRWNH ; VKKFLERSGP ; 100: FTHPDFEPST ; ESLQFLLDTC ; KVLVIGAGGL ; GCELLKNLAL ; SGFRQIHVID ; 150: MDTIDVSNLN ; RQFLFRPKDI ; GRPKAEVAAE ; FLNDRVPNCN ; VVPHFNKIQD ; 200: FNDTFYRQFH ; IIVCGLDSII ; ARRWINGMLI ; SLLNYEDGVL ; DPSSIVPLID ; 250: GGTEGFKGNA ; RVILPGMTAC ; IECTLELYPP ; QVNFPMCTIA ; SMPRLPEHCI ; 300: EYVRMLQWPK ; EQPFGEGVPL ; DGDDPEHIQW ; IFQKSLERAS ; QYNIRGVTYR ; 350: LTQGVVKRII ; PAVASTNAVI ; AAVCATEVFK ; IATSAYIPLN ; NYLVFNDVDG ; 400: LYTYTFEAER ; KENCPACSQL ; PQNIQFSPSA ; KLQEVLDYLT ; NSASLQMKSP ; 450: AITATLEGKN ; RTLYLQSVTS ; IEERTRPNLS ; KTLKELGLVD ; GQELAVADVT ; 463: TPQTVLFKLH ; FTS
Sequence Length	463
String	Q8TBC4
Sub Unit	Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand.

Uniprot	Q8TBC4
Gene Name	UBA3
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:9039
Unigene	Hs.154320

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811522	E1027h	96T	$736		Add to Cart

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