Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signaling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Isoform 3 is not functional. Isoform 4 displays an increased activity. Isoform 5 and isoform 6 display reduced activity.
Specificity
Natural and recombinant Human NADPH oxidase 4
Subcellular Location
Endoplasmic reticulum membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Cell junction focal adhesion Nucleus May localize to plasma membrane and focal adhesions. According to PubMed:15927447, may also localize to the nucleus.