JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

SKU : BHE13809578

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E0341h
Alternative Names	NAD-dependent ADP-ribosyltransferase sirtuin-4 ; 2.4.2.- ; NAD-dependent protein deacetylase sirtuin-4 ; 3.5.1.- ; Regulatory protein SIR2 homolog 4 ; SIR2-like protein 4 ; SIR2L4
Categories	Elisa
Function	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
Specificity	Natural and recombinant Human NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Subcellular Location	Mitochondrion matrix
Entryname	SIR4_HUMAN
Platform	PF02146
Protein Name	NAD-dependent protein lipoamidase sirtuin-4, mitochondrial
Sequence	50: MKMSFALTFR ; SAKGRWIANP ; SQPCSKASIG ; LFVPASPPLD ; PEKVKELQRF ; 100: ITLSKRLLVM ; TGAGISTESG ; IPDYRSEKVG ; LYARTDRRPI ; QHGDFVRSAP ; 150: IRQRYWARNF ; VGWPQFSSHQ ; PNPAHWALST ; WEKLGKLYWL ; VTQNVDALHT ; 200: KAGSRRLTEL ; HGCMDRVLCL ; DCGEQTPRGV ; LQERFQVLNP ; TWSAEAHGLA ; 250: PDGDVFLSEE ; QVRSFQVPTC ; VQCGGHLKPD ; VVFFGDTVNP ; DKVDFVHKRV ; 300: KEADSLLVVG ; SSLQVYSGYR ; FILTAWEKKL ; PIAILNIGPT ; RSDDLACLKL ; 314: NSRCGELLPL ; IDPC
Sequence Length	314
Sub Unit	Interacts with GLUD1, IDE and SLC25A5.

Uniprot	Q9Y6E7
Gene Name	SIRT4
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:23409
Unigene	Hs.50861

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13809578	E0341h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.