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Home / Assay Kits / ELISA Kits

ELISA Kit for Human NAD-dependent protein deacylase sirtuin-5, mitochondrial

SKU : BHE13810172

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E11384h
Alternative Names	Regulatory protein SIR2 homolog 5 ; SIR2-like protein 5 ; SIR2L5
Categories	Elisa
Function	NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
Specificity	Natural and recombinant Human NAD-dependent protein deacylase sirtuin-5, mitochondrial
Subcellular Location	Isoform 2 Mitochondrion
Detection Range	0.156-10ng/mL
Entryname	SIR5_HUMAN
Method Type	Sandwich
Platform	PF02146
Protein Name	NAD-dependent protein deacylase sirtuin-5, mitochondrial
Sensitivity	0.067ng/mL
Sequence	50: MRPLQIVPSR ; LISQLYCGLK ; PPASTRNQIC ; LKMARPSSSM ; ADFRKFFAKA ; 100: KHIVIISGAG ; VSAESGVPTF ; RGAGGYWRKW ; QAQDLATPLA ; FAHNPSRVWE ; 150: FYHYRREVMG ; SKEPNAGHRA ; IAECETRLGK ; QGRRVVVITQ ; NIDELHRKAG ; 200: TKNLLEIHGS ; LFKTRCTSCG ; VVAENYKSPI ; CPALSGKGAP ; EPGTQDASIP ; 250: VEKLPRCEEA ; GCGGLLRPHV ; VWFGENLDPA ; ILEEVDRELA ; HCDLCLVVGT ; 300: SSVVYPAAMF ; APQVAARGVP ; VAEFNTETTP ; ATNRFRFHFQ ; GPCGTTLPEA ; 310: LACHENETVS ;
Sequence Length	310
Sub Unit	Interacts with CPS1 (By similarity). Monomer. Homodimer. Forms homodimers upon suramin binding.

Uniprot	Q9NXA8
Gene Name	SIRT5
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:23408
Unigene	Hs.567431

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810172	E11384h	96T	$736		Add to Cart

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