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Home / Assay Kits / ELISA Kits

ELISA Kit for Human NAD-dependent deacetylase sirtuin-6

SKU : BHE13811057

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2127h
Alternative Names	SIR2-like protein 6 ; SIR2L6
Categories	Elisa
Function	NAD-dependent protein deacetylase. Has deacetylase activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates 'Lys-9' of histone H3 at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.
Specificity	Natural and recombinant Human NAD-dependent deacetylase sirtuin-6
Subcellular Location	Nucleus nucleoplasm Predominantly nuclear. Associated with telomeric heterochromatin regions.
Detection Range	78-5000pg/mL
Entryname	SIRT6_HUMAN
Method Type	Sandwich
Platform	PF02146
Protein Name	NAD-dependent deacetylase sirtuin-6
Sensitivity	20pg/mL
Sequence	50: MSVNYAAGLS ; PYADKGKCGL ; PEIFDPPEEL ; ERKVWELARL ; VWQSSSVVFH ; 100: TGAGISTASG ; IPDFRGPHGV ; WTMEERGLAP ; KFDTTFESAR ; PTQTHMALVQ ; 150: LERVGLLRFL ; VSQNVDGLHV ; RSGFPRDKLA ; ELHGNMFVEE ; CAKCKTQYVR ; 200: DTVVGTMGLK ; ATGRLCTVAK ; ARGLRACRGE ; LRDTILDWED ; SLPDRDLALA ; 250: DEASRNADLS ; ITLGTSLQIR ; PSGNLPLATK ; RRGGRLVIVN ; LQPTKHDRHA ; 300: DLRIHGYVDE ; VMTRLMKHLG ; LEIPAWDGPR ; VLERALPPLP ; RPPTPKLEPK ; 350: EESPTRINGS ; IPAGPKQEPC ; AQHNGSEPAS ; PKRERPTSPA ; PHRPPKRVKA ; 355: KAVPS
Sequence Length	355
String	Q8N6T7
Sub Unit	Interacts with RELA.

Uniprot	Q8N6T7
Gene Name	SIRT6
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:51548
Unigene	Hs.423756

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SKU	Supplier No.	Size	Your price	Quantity
BHE13811057	E2127h	96T	$736		Add to Cart

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