NAD-dependent protein deacetylase that activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting. Deacetylates CPS1 and increases CPS1 activity in response to elevated NAD levels during fasting (By similarity). Can deacetylate cytochrome c and a number of other proteins (in vitro).
Specificity
Natural and recombinant Human NAD-dependent deacetylase sirtuin-5
Subcellular Location
Mitochondrion matrix Mitochondrion intermembrane space