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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Muscleblind-like protein 1

SKU : BHE13806564

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15209h
Alternative Names	Triplet-expansion RNA-binding protein ; EXP ; KIAA0428 ; MBNL
Categories	Elisa
Function	Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
Specificity	Natural and recombinant Human Muscleblind-like protein 1
Subcellular Location	Nucleus Cytoplasm Cytoplasmic granule Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes. Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy.
Detection Range	0.312-20ng/mL
Entryname	MBNL1_HUMAN
Method Type	Sandwich
Platform	PF00642
Protein Name	Muscleblind-like protein 1
Sensitivity	0.139ng/mL
Sequence	50: MAVSVTPIRD ; TKWLTLEVCR ; EFQRGTCSRP ; DTECKFAHPS ; KSCQVENGRV ; 100: IACFDSLKGR ; CSRENCKYLH ; PPPHLKTQLE ; INGRNNLIQQ ; KNMAMLAQQM ; 150: QLANAMMPGA ; PLQPVPMFSV ; APSLATNASA ; AAFNPYLGPV ; SPSLVPAEIL ; 200: PTAPMLVTGN ; PGVPVPAAAA ; AAAQKLMRTD ; RLEVCREYQR ; GNCNRGENDC ; 250: RFAHPADSTM ; IDTNDNTVTV ; CMDYIKGRCS ; REKCKYFHPP ; AHLQAKIKAA ; 300: QYQVNQAAAA ; QAAATAAAMT ; QSAVKSLKRP ; LEATFDLGIP ; QAVLPPLPKR ; 350: PALEKTNGAT ; AVFNTGIFQY ; QQALANMQLQ ; QHTAFLPPVP ; MVHGATPATV ; 388: SAATTSATSV ; PFAATATANQ ; IPIISAEHLT ; SHKYVTQM
Sequence Length	388
String	Q9NR56
Sub Unit	Interacts with DDX1 and YBX1. Interacts with HNRNPH1; the interaction in RNA-independent.

Uniprot	Q9NR56
Gene Name	MBNL1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4154
Unigene	Hs.201858

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806564	E15209h	96T	$736		Add to Cart

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