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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Mothers against decapentaplegic homolog 7

SKU : BHE13810235

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0648h
Alternative Names	Mothers against decapentaplegic homolog 8 ; MAD homolog 8 ; SMAD family member 7 ; SMAD 7 ; MADH7 ; MADH8
Categories	Elisa
Function	Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation.
Specificity	Natural and recombinant Human Mothers against decapentaplegic homolog 7
Subcellular Location	Nucleus Cytoplasm Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm.
Detection Range	0.156-10ng/mL
Entryname	SMAD7_HUMAN
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 7
Sensitivity	0.1ng/mL
Sequence	50: MFRTKRSALV ; RRLWRSRAPG ; GEDEEEGAGG ; GGGGGELRGE ; GATDSRAHGA ; 100: GGGGPGRAGC ; CLGKAVRGAK ; GHHHPHPPAA ; GAGAAGGAEA ; DLKALTHSVL ; 150: KKLKERQLEL ; LLQAVESRGG ; TRTACLLLPG ; RLDCRLGPGA ; PAGAQPAQPP ; 200: SSYSLPLLLC ; KVFRWPDLRH ; SSEVKRLCCC ; ESYGKINPEL ; VCCNPHHLSR ; 250: LCELESPPPP ; YSRYPMDFLK ; PTADCPDAVP ; SSAETGGTNY ; LAPGGLSDSQ ; 300: LLLEPGDRSH ; WCVVAYWEEK ; TRVGRLYCVQ ; EPSLDIFYDL ; PQGNGFCLGQ ; 350: LNSDNKSQLV ; QKVRSKIGCG ; IQLTREVDGV ; WVYNRSSYPI ; FIKSATLDNP ; 400: DSRTLLVHKV ; FPGFSIKAFD ; YEKAYSLQRP ; NDHEFMQQPW ; TGFTVQISFV ; 426: KGWGQCYTRQ ; FISSCPCWLE ; VIFNSR
Sequence Length	426
String	O15105
Sub Unit	Interacts with WWP1 (By similarity). Interacts with COPS5. Interacts with NEDD4L. Interacts with STAMBP. Interacts with RNF111, AXIN1 and AXIN2. Interacts with PPP1R15A. Interacts (via MH2 domain) with EP300. Interacts with ACVR1B, SMURF1, SMURF2 and TGFBR1; SMAD7 recruits SMURF1 and SMURF2 to the TGF-beta receptor and regulates its degradation.

Uniprot	O15105
Gene Name	SMAD7
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4092
Unigene	Hs.465087

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810235	E0648h	96T	$736		Add to Cart

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