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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Mothers against decapentaplegic homolog 1

SKU : BHE13810053

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0647h
Alternative Names	JV4-1 ; Mad-related protein 1 ; SMAD family member 1 ; SMAD 1 ; Transforming growth factor-beta-signaling protein 1 ; BSP-1 ; BSP1 ; MADH1 ; MADR1
Categories	Elisa
Function	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1.
Specificity	Natural and recombinant Human Mothers against decapentaplegic homolog 1
Subcellular Location	Cytoplasm Nucleus Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. Co-localizes with LEMD3 at the nucleus inner membrane.
Detection Range	15.6-1000pg/mL
Entryname	SMAD1_HUMAN
Method Type	Sandwich
Platform	PF03165
Protein Name	Mothers against decapentaplegic homolog 1
Sensitivity	8.9pg/mL
Sequence	50: MNVTSLFSFT ; SPAVKRLLGW ; KQGDEEEKWA ; EKAVDALVKK ; LKKKKGAMEE ; 100: LEKALSCPGQ ; PSNCVTIPRS ; LDGRLQVSHR ; KGLPHVIYCR ; VWRWPDLQSH ; 150: HELKPLECCE ; FPFGSKQKEV ; CINPYHYKRV ; ESPVLPPVLV ; PRHSEYNPQH ; 200: SLLAQFRNLG ; QNEPHMPLNA ; TFPDSFQQPN ; SHPFPHSPNS ; SYPNSPGSSS ; 250: STYPHSPTSS ; DPGSPFQMPA ; DTPPPAYLPP ; EDPMTQDGSQ ; PMDTNMMAPP ; 300: LPSEINRGDV ; QAVAYEEPKH ; WCSIVYYELN ; NRVGEAFHAS ; STSVLVDGFT ; 350: DPSNNKNRFC ; LGLLSNVNRN ; STIENTRRHI ; GKGVHLYYVG ; GEVYAECLSD ; 400: SSIFVQSRNC ; NYHHGFHPTT ; VCKIPSGCSL ; KIFNNQEFAQ ; LLAQSVNHGF ; 450: ETVYELTKMC ; TIRMSFVKGW ; GAEYHRQDVT ; STPCWIEIHL ; HGPLQWLDKV ; 465: LTQMGSPHNP ; ISSVS
Sequence Length	465
String	Q15797
Sub Unit	Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome.

Uniprot	Q15797
Gene Name	SMAD1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4086
Unigene	Hs.604588

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SKU	Supplier No.	Size	Your price	Quantity
BHE13810053	E0647h	96T	$736		Add to Cart

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