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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Mitotic spindle assembly checkpoint protein MAD1

SKU : BHE13806858

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E5695h
Alternative Names	Mitotic arrest deficient 1-like protein 1 ; MAD1-like protein 1 ; Mitotic checkpoint MAD1 protein homolog ; HsMAD1 ; Tax-binding protein 181 ; MAD1 ; TXBP181
Categories	Elisa
Function	Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.
Specificity	Natural and recombinant Human Mitotic spindle assembly checkpoint protein MAD1
Subcellular Location	Nucleus Chromosome centromere kinetochore Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle From the beginning to the end of mitosis, it is seen to move from a diffusely nuclear distribution to the centrosome, to the spindle midzone and finally to the midbody. Co-localizes with NEK2 at the kinetochore.
Detection Range	0.156-10ng/mL
Entryname	MD1L1_HUMAN
Method Type	Sandwich
Platform	PF05557
Protein Name	Mitotic spindle assembly checkpoint protein MAD1
Sensitivity	0.078ng/mL
Sequence	50: MEDLGENTMV ; LSTLRSLNNF ; ISQRVEGGSG ; LDISTSAPGS ; LQMQYQQSMQ ; 100: LEERAEQIRS ; KSHLIQVERE ; KMQMELSHKR ; ARVELERAAS ; TSARNYEREV ; 150: DRNQELLTRI ; RQLQEREAGA ; EEKMQEQLER ; NRQCQQNLDA ; ASKRLREKED ; 200: SLAQAGETIN ; ALKGRISELQ ; WSVMDQEMRV ; KRLESEKQEL ; QEQLDLQHKK ; 250: CQEANQKIQE ; LQASQEARAD ; HEQQIKDLEQ ; KLSLQEQDAA ; IVKNMKSELV ; 300: RLPRLERELK ; QLREESAHLR ; EMRETNGLLQ ; EELEGLQRKL ; GRQEKMQETL ; 350: VGLELENERL ; LAKLQSWERL ; DQTMGLSIRT ; PEDLSRFVVE ; LQQRELALKD ; 400: KNSAVTSSAR ; GLEKARQQLQ ; EELRQVSGQL ; LEERKKRETH ; EALARRLQKR ; 450: VLLLTKERDG ; MRAILGSYDS ; ELTPAEYSPQ ; LTRRMREAED ; MVQKVHSHSA ; 500: EMEAQLSQAL ; EELGGQKQRA ; DMLEMELKML ; KSQSSSAEQS ; FLFSREEADT ; 550: LRLKVEELEG ; ERSRLEEEKR ; MLEAQLERRA ; LQGDYDQSRT ; KVLHMSLNPT ; 600: SVARQRLRED ; HSQLQAECER ; LRGLLRAMER ; GGTVPADLEA ; AAASLPSSKE ; 650: VAELKKQVES ; AELKNQRLKE ; VFQTKIQEFR ; KACYTLTGYQ ; IDITTENQYR ; 700: LTSLYAEHPG ; DCLIFKATSP ; SGSKMQLLET ; EFSHTVGELI ; EVHLRRQDSI ; 718: PAFLSSLTLE ; LFSRQTVA
Sequence Length	718
String	Q9Y6D9
Sub Unit	Homodimer. Heterodimerizes with MAD2L1 in order to form a tetrameric MAD1L1-MAD2L1 core complex. Perturbation of the original MAD1L1-MAD2L1 structure by the spindle checkpoint may decrease MAD2L1 affinity for MAD1L1. CDC20 can compete with MAD1L1 for MAD2L1 binding, until the attachment and/or tension dampen the checkpoint signal, preventing further release of MAD2L1 on to CDC20. Also able to interact with the BUB1/BUB3 complex and the viral Tax protein. Interacts with TPR and NEK2.

Uniprot	Q9Y6D9
Gene Name	MAD1L1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8379
Unigene	Hs.654838

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806858	E5695h	96T	$736		Add to Cart

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