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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 7

SKU : BHE13806897

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10349h
Antigen	MAP3K7
Alternative Names	Transforming growth factor-beta-activated kinase 1 ; TGF-beta-activated kinase 1 ; TAK1
Categories	Elisa
Function	Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.
Specificity	Natural and recombinant Human Mitogen-activated protein kinase kinase kinase 7
Entryname	M3K7_HUMAN
Platform	PF07714
Protein Name	Mitogen-activated protein kinase kinase kinase 7
Sequence	50: MSTASAASSS ; SSSSAGEMIE ; APSQVLNFEE ; IDYKEIEVEE ; VVGRGAFGVV ; 100: CKAKWRAKDV ; AIKQIESESE ; RKAFIVELRQ ; LSRVNHPNIV ; KLYGACLNPV ; 150: CLVMEYAEGG ; SLYNVLHGAE ; PLPYYTAAHA ; MSWCLQCSQG ; VAYLHSMQPK ; 200: ALIHRDLKPP ; NLLLVAGGTV ; LKICDFGTAC ; DIQTHMTNNK ; GSAAWMAPEV ; 250: FEGSNYSEKC ; DVFSWGIILW ; EVITRRKPFD ; EIGGPAFRIM ; WAVHNGTRPP ; 300: LIKNLPKPIE ; SLMTRCWSKD ; PSQRPSMEEI ; VKIMTHLMRY ; FPGADEPLQY ; 350: PCQYSDEGQS ; NSATSTGSFM ; DIASTNTSNK ; SDTNMEQVPA ; TNDTIKRLES ; 400: KLLKNQAKQQ ; SESGRLSLGA ; SRGSSVESLP ; PTSEGKRMSA ; DMSEIEARIA ; 450: ATTAYSKPKR ; GHRKTASFGN ; ILDVPEIVIS ; GNGQPRRRSI ; QDLTVTGTEP ; 500: GQVSSRSSSP ; SVRMITTSGP ; TSEKPTRSHP ; WTPDDSTDTN ; GSDNSIPMAY ; 550: LTLDHQLQPL ; APCPNSKESM ; AVFEQHCKMA ; QEYMKVQTEI ; ALLLQRKQEL ; 600: VAELDQDEKD ; QQNTSRLVQE ; HKKLLDENKS ; LSTYYQQCKK ; QLEVIRSQQQ ; 606: KRQGTS
Sequence Length	606
String	O43318
Sub Unit	Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Identified in the TRIKA2 complex composed of MAP3K7, TAB1/MAP3K7IP1 and TAB2/MAP3K7IP2. Interacts with PPM1L. Interaction with PP2A and PPP6C leads to its repressed activity. Interacts with TRAF6 and TAB1/MAP3K7IP1; during IL-1 signaling. Interacts with TAOK1 and TAOK2; interaction with TAOK2 interferes with MAP3K7 interaction with IKKA, thus preventing NF-kappa-B activation. Interacts with WDR34 (via WD domains). Interacts with RBCK1. Interacts with CYLD. Interacts with TGFBR1; induces MAP3K7 activation by TRAF6. Interacts with MAPK8IP1 (By similarity). Interacts with isoform 1 of VRK2.

Uniprot	O43318
Gene Name	MAP3K7
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:6885
Unigene	Hs.722892

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806897	E10349h	96T	$736		Add to Cart

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