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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Mitogen-activated protein kinase kinase kinase 5

SKU : BHE13806720

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1358h
Alternative Names	Apoptosis signal-regulating kinase 1 ; ASK-1 ; MAPK/ERK kinase kinase 5 ; MEK kinase 5 ; ASK1 ; MAPKKK5 ; MEKK5
Categories	Elisa
Function	Component of a protein kinase signal transduction cascade. Phosphorylates and activates MAP2K4 and MAP2K6, which in turn activate the JNK and p38 MAP kinases, respectively. Overexpression induces apoptotic cell death.
Specificity	Natural and recombinant Human Mitogen-activated protein kinase kinase kinase 5
Subcellular Location	Cytoplasm
Detection Range	0.312-20ng/mL
Entryname	M3K5_HUMAN
Method Type	Sandwich
Platform	PF13281
Protein Name	Mitogen-activated protein kinase kinase kinase 5
Sensitivity	0.196ng/mL
Sequence	50: MSTEADEGIT ; FSVPPFAPSG ; FCTIPEGGIC ; RRGGAAAVGE ; GEEHQLPPPP ; 100: PGSFWNVESA ; AAPGIGCPAA ; TSSSSATRGR ; GSSVGGGSRR ; TTVAYVINEA ; 150: SQGQLVVAES ; EALQSLREAC ; ETVGATLETL ; HFGKLDFGET ; TVLDRFYNAD ; 200: IAVVEMSDAF ; RQPSLFYHLG ; VRESFSMANN ; IILYCDTNSD ; SLQSLKEIIC ; 250: QKNTMCTGNY ; TFVPYMITPH ; NKVYCCDSSF ; MKGLTELMQP ; NFELLLGPIC ; 300: LPLVDRFIQL ; LKVAQASSSQ ; YFRESILNDI ; RKARNLYTGK ; ELAAELARIR ; 350: QRVDNIEVLT ; ADIVINLLLS ; YRDIQDYDSI ; VKLVETLEKL ; PTFDLASHHH ; 400: VKFHYAFALN ; RRNLPGDRAK ; ALDIMIPMVQ ; SEGQVASDMY ; CLVGRIYKDM ; 450: FLDSNFTDTE ; SRDHGASWFK ; KAFESEPTLQ ; SGINYAVLLL ; AAGHQFESSF ; 500: ELRKVGVKLS ; SLLGKKGNLE ; KLQSYWEVGF ; FLGASVLAND ; HMRVIQASEK ; 550: LFKLKTPAWY ; LKSIVETILI ; YKHFVKLTTE ; QPVAKQELVD ; FWMDFLVEAT ; 600: KTDVTVVRFP ; VLILEPTKIY ; QPSYLSINNE ; VEEKTISIWH ; VLPDDKKGIH ; 650: EWNFSASSVR ; GVSISKFEER ; CCFLYVLHNS ; DDFQIYFCTE ; LHCKKFFEMV ; 700: NTITEEKGRS ; TEEGDCESDL ; LEYDYEYDEN ; GDRVVLGKGT ; YGIVYAGRDL ; 750: SNQVRIAIKE ; IPERDSRYSQ ; PLHEEIALHK ; HLKHKNIVQY ; LGSFSENGFI ; 800: KIFMEQVPGG ; SLSALLRSKW ; GPLKDNEQTI ; GFYTKQILEG ; LKYLHDNQIV ; 850: HRDIKGDNVL ; INTYSGVLKI ; SDFGTSKRLA ; GINPCTETFT ; GTLQYMAPEI ; 900: IDKGPRGYGK ; AADIWSLGCT ; IIEMATGKPP ; FYELGEPQAA ; MFKVGMFKVH ; 950: PEIPESMSAE ; AKAFILKCFE ; PDPDKRACAN ; DLLVDEFLKV ; SSKKKKTQPK ; 1000: LSALSAGSNE ; YLRSISLPVP ; VLVEDTSSSS ; EYGSVSPDTE ; LKVDPFSFKT ; 1050: RAKSCGERDV ; KGIRTLFLGI ; PDENFEDHSA ; PPSPEEKDSG ; FFMLRKDSER ; 1100: RATLHRILTE ; DQDKIVRNLM ; ESLAQGAEEP ; KLKWEHITTL ; IASLREFVRS ; 1150: TDRKIIATTL ; SKLKLELDFD ; SHGISQVQVV ; LFGFQDAVNK ; VLRNHNIKPH ; 1200: WMFALDSIIR ; KAVQTAITIL ; VPELRPHFSL ; ASESDTADQE ; DLDVEDDHEE ; 1250: QPSNQTVRRP ; QAVIEDAVAT ; SGVSTLSSTV ; SHDSQSAHRS ; LNVQLGRMKI ; 1300: ETNRLLEELV ; RKEKELQALL ; HRAIEEKDQE ; IKHLKLKSQP ; IEIPELPVFH ; 1350: LNSSGTNTED ; SELTDWLRVN ; GADEDTISRF ; LAEDYTLLDV ; LYYVTRDDLK ; 1374: CLRLRGGMLC ; TLWKAIIDFR ; NKQT
Sequence Length	1374
String	Q99683
Sub Unit	Homodimer when inactive. Binds both upstream activators and downstream substrates in multimolecular complexes. Associates with and inhibited by HIV-1 Nef. Interacts with DAB2IP and PPM1L. Interacts with ARRB2. Part of a cytoplasmic complex made of HIPK1, DAB2IP and MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis.

Uniprot	Q99683
Gene Name	MAP3K5
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4217
Unigene	Hs.186486

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806720	E1358h	96T	$736		Add to Cart

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