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Home / Assay Kits / ELISA Kits

ELISA Kit for Human MHC class I polypeptide-related sequence B

SKU : BHE13806522

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E15292h
Alternative Names	PERB11.2
Categories	Elisa
Function	Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Specificity	Natural and recombinant Human MHC class I polypeptide-related sequence B
Subcellular Location	Cell membrane Single-pass type I membrane protein Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
Detection Range	31.2-2000pg/mL
Entryname	MICB_HUMAN
Method Type	Sandwich
Platform	PF07654
Protein Name	MHC class I polypeptide-related sequence B
Sensitivity	14.4pg/mL
Sequence	50: MGLGRVLLFL ; AVAFPFAPPA ; AAAEPHSLRY ; NLMVLSQDES ; VQSGFLAEGH ; 100: LDGQPFLRYD ; RQKRRAKPQG ; QWAEDVLGAK ; TWDTETEDLT ; ENGQDLRRTL ; 150: THIKDQKGGL ; HSLQEIRVCE ; IHEDSSTRGS ; RHFYYDGELF ; LSQNLETQES ; 200: TVPQSSRAQT ; LAMNVTNFWK ; EDAMKTKTHY ; RAMQADCLQK ; LQRYLKSGVA ; 250: IRRTVPPMVN ; VTCSEVSEGN ; ITVTCRASSF ; YPRNITLTWR ; QDGVSLSHNT ; 300: QQWGDVLPDG ; NGTYQTWVAT ; RIRQGEEQRF ; TCYMEHSGNH ; GTHPVPSGKV ; 350: LVLQSQRTDF ; PYVSAAMPCF ; VIIIILCVPC ; CKKKTSAAEG ; PELVSLQVLD ; 383: QHPVGTGDHR ; DAAQLGFQPL ; MSATGSTGST ; EGA
Sequence Length	383
String	Q29980
Sub Unit	Unlike classical MHC class I molecules, does not form a heterodimer with beta-2-microglobulin. Binds as a monomer to a KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which KLRK1 binds MICB while HCST acts as an adapter molecule which enables signal transduction. Receptor-ligand interaction induces clustering of both proteins in ordered structures called immune synapses and also leads to their intercellular transfer. This is associated with a reduction in the cytotoxicity of KLRK1-expressing cells. Binds to human cytomegalovirus glycoprotein UL16 which causes sequestration of MICB in the endoplasmic reticulum and increases resistance to KLRK1-mediated cytotoxicity.

Uniprot	Q29980
Gene Name	MICB
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4277
Unigene	Hs.130838

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806522	E15292h	96T	$736		Add to Cart

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