Modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK. Substrate of CSBP. In vitro, phosphorylates HSPB1, BMI1/PCGF4 and TCF3.
Specificity
Natural and recombinant Human MAP kinase-activated protein kinase 3
Subcellular Location
Nucleus Cytoplasm Predominantly located in the nucleus, when activated it translocates to the cytoplasm.