JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Assay Kits / ELISA Kits

ELISA Kit for Human Low-density lipoprotein receptor-related protein 6

SKU : BHE13806752

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

EIAAB SCIENCE INC, WUHAN

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	E1010h
Categories	Elisa
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation.
Specificity	Natural and recombinant Human Low-density lipoprotein receptor-related protein 6
Subcellular Location	Membrane Single-pass type I membrane protein Endoplasmic reticulum On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD.
Detection Range	0.78-50ng/mL
Entryname	LRP6_HUMAN
Method Type	Sandwich
Platform	PF00057
Protein Name	Low-density lipoprotein receptor-related protein 6
Sensitivity	0.56ng/mL
Sequence	50: MGAVLRSLLA ; CSFCVLLRAA ; PLLLYANRRD ; LRLVDATNGK ; ENATIVVGGL ; 100: EDAAAVDFVF ; SHGLIYWSDV ; SEEAIKRTEF ; NKTESVQNVV ; VSGLLSPDGL ; 150: ACDWLGEKLY ; WTDSETNRIE ; VSNLDGSLRK ; VLFWQELDQP ; RAIALDPSSG ; 200: FMYWTDWGEV ; PKIERAGMDG ; SSRFIIINSE ; IYWPNGLTLD ; YEEQKLYWAD ; 250: AKLNFIHKSN ; LDGTNRQAVV ; KGSLPHPFAL ; TLFEDILYWT ; DWSTHSILAC ; 300: NKYTGEGLRE ; IHSDIFSPMD ; IHAFSQQRQP ; NATNPCGIDN ; GGCSHLCLMS ; 350: PVKPFYQCAC ; PTGVKLLENG ; KTCKDGATEL ; LLLARRTDLR ; RISLDTPDFT ; 400: DIVLQLEDIR ; HAIAIDYDPV ; EGYIYWTDDE ; VRAIRRSFID ; GSGSQFVVTA ; 450: QIAHPDGIAV ; DWVARNLYWT ; DTGTDRIEVT ; RLNGTMRKIL ; ISEDLEEPRA ; 500: IVLDPMVGYM ; YWTDWGEIPK ; IERAALDGSD ; RVVLVNTSLG ; WPNGLALDYD ; 550: EGKIYWGDAK ; TDKIEVMNTD ; GTGRRVLVED ; KIPHIFGFTL ; LGDYVYWTDW ; 600: QRRSIERVHK ; RSAEREVIID ; QLPDLMGLKA ; TNVHRVIGSN ; PCAEENGGCS ; 650: HLCLYRPQGL ; RCACPIGFEL ; ISDMKTCIVP ; EAFLLFSRRA ; DIRRISLETN ; 700: NNNVAIPLTG ; VKEASALDFD ; VTDNRIYWTD ; ISLKTISRAF ; MNGSALEHVV ; 750: EFGLDYPEGM ; AVDWLGKNLY ; WADTGTNRIE ; VSKLDGQHRQ ; VLVWKDLDSP ; 800: RALALDPAEG ; FMYWTEWGGK ; PKIDRAAMDG ; SERTTLVPNV ; GRANGLTIDY ; 850: AKRRLYWTDL ; DTNLIESSNM ; LGLNREVIAD ; DLPHPFGLTQ ; YQDYIYWTDW ; 900: SRRSIERANK ; TSGQNRTIIQ ; GHLDYVMDIL ; VFHSSRQSGW ; NECASSNGHC ; 950: SHLCLAVPVG ; GFVCGCPAHY ; SLNADNRTCS ; APTTFLLFSQ ; KSAINRMVID ; 1000: EQQSPDIILP ; IHSLRNVRAI ; DYDPLDKQLY ; WIDSRQNMIR ; KAQEDGSQGF ; 1050: TVVVSSVPSQ ; NLEIQPYDLS ; IDIYSRYIYW ; TCEATNVINV ; TRLDGRSVGV ; 1100: VLKGEQDRPR ; AVVVNPEKGY ; MYFTNLQERS ; PKIERAALDG ; TEREVLFFSG ; 1150: LSKPIALALD ; SRLGKLFWAD ; SDLRRIESSD ; LSGANRIVLE ; DSNILQPVGL ; 1200: TVFENWLYWI ; DKQQQMIEKI ; DMTGREGRTK ; VQARIAQLSD ; IHAVKELNLQ ; 1250: EYRQHPCAQD ; NGGCSHICLV ; KGDGTTRCSC ; PMHLVLLQDE ; LSCGEPPTCS ; 1300: PQQFTCFTGE ; IDCIPVAWRC ; DGFTECEDHS ; DELNCPVCSE ; SQFQCASGQC ; 1350: IDGALRCNGD ; ANCQDKSDEK ; NCEVLCLIDQ ; FRCANGQCIG ; KHKKCDHNVD ; 1400: CSDKSDELDC ; YPTEEPAPQA ; TNTVGSVIGV ; IVTIFVSGTV ; YFICQRMLCP ; 1450: RMKGDGETMT ; NDYVVHGPAS ; VPLGYVPHPS ; SLSGSLPGMS ; RGKSMISSLS ; 1500: IMGGSSGPPY ; DRAHVTGASS ; SSSSSTKGTY ; FPAILNPPPS ; PATERSHYTM ; 1550: EFGYSSNSPS ; THRSYSYRPY ; SYRHFAPPTT ; PCSTDVCDSD ; YAPSRRMTSV ; 1600: ATAKGYTSDL ; NYDSEPVPPP ; PTPRSQYLSA ; EENYESCPPS ; PYTERSYSHH ; 1613: LYPPPPSPCT ; DSS
Sequence Length	1613
String	O75581
Sub Unit	Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling. Forms a WNT-signaling complex formed of a WNT protein, a FZD protein and LRP5 or LRP6. Interacts (via the extracellular domain) with WNT1; the interaction is enhanced by prior formation of the Wnt/Fzd complex. Interacts (via the beta-propeller regions 3 and 4) with WNT3A. Interacts (via the beta-propeller regions 1 and 2) with WNT9B. Interacts with FZD5; the interaction forms a coreceptor complex for Wnt signaling and is inhibited by DKK1 and C1orf187. Interacts (via beta propeller regions 3 and 4) with DKK1; the interaction inhibits FZD5/LRP6 complex formation. Interacts with DKK2. Interacts with C1orf187/DRAXIN; the interaction inhibits Wnt signaling (By similarity). Interacts (via the phosphorylated PPPSP motifs) with AXIN1; the interaction recruits the AXIN1/GSK3B complex to cell surface LRP6 signalsomes. Interacts with GRB10; the interaction prevents AXIN1 binding, thus negatively regulating the Wnt signaling pathway (By similarity). Interacts (via the extracellular domain) with RSPO1; the interaction activates Wnt/beta-catenin signaling. Interacts (via the extracellular domain) with RSPO3 (via the cysteine rich domain); the interaction activates Wnt/beta-catenin signaling. Interacts (via the beta-propeller regions 1 and 2) with SOST; the interaction competes with DKK1 for binding for inhibiting beta-catenin signaling. Interacts with MESD; the interaction prevents the formation of LRP6 aggregates and targets LRP6 to the plasma membrane (By similarity). Interacts (via the cytoplasmic domain) with CSNKIE; the interaction phosphorylates LRP6, binds AXIN1 and inhibits AXIN1/GSK3B-mediated phosphorylation of beta-catenin. Interacts with MACF1.

Uniprot	O75581
Gene Name	LRP6
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4040
Unigene	Hs.584775

Have you used this product?

Rate it now..!!

Login to Review

SKU	Supplier No.	Size	Your price	Quantity
BHE13806752	E1010h	96T	$736		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2024 Biohippo. All rights reserved.