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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Low-density lipoprotein receptor-related protein 5

SKU : BHE13806059

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E3681h
Alternative Names	LR3 ; LRP7
Categories	Elisa
Function	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye. Required for posterior patterning of the epiblast during gastrulation.
Specificity	Natural and recombinant Human Low-density lipoprotein receptor-related protein 5
Subcellular Location	Membrane Single-pass type I membrane protein Endoplasmic reticulum Chaperoned to the plasma membrane by MESD.
Detection Range	0.312-20ng/mL
Entryname	LRP5_HUMAN
Method Type	Sandwich
Platform	PF00057
Protein Name	Low-density lipoprotein receptor-related protein 5
Sensitivity	0.19ng/mL
Sequence	50: MEAAPPGPPW ; PLLLLLLLLL ; ALCGCPAPAA ; ASPLLLFANR ; RDVRLVDAGG ; 100: VKLESTIVVS ; GLEDAAAVDF ; QFSKGAVYWT ; DVSEEAIKQT ; YLNQTGAAVQ ; 150: NVVISGLVSP ; DGLACDWVGK ; KLYWTDSETN ; RIEVANLNGT ; SRKVLFWQDL ; 200: DQPRAIALDP ; AHGYMYWTDW ; GETPRIERAG ; MDGSTRKIIV ; DSDIYWPNGL ; 250: TIDLEEQKLY ; WADAKLSFIH ; RANLDGSFRQ ; KVVEGSLTHP ; FALTLSGDTL ; 300: YWTDWQTRSI ; HACNKRTGGK ; RKEILSALYS ; PMDIQVLSQE ; RQPFFHTRCE ; 350: EDNGGCSHLC ; LLSPSEPFYT ; CACPTGVQLQ ; DNGRTCKAGA ; EEVLLLARRT ; 400: DLRRISLDTP ; DFTDIVLQVD ; DIRHAIAIDY ; DPLEGYVYWT ; DDEVRAIRRA ; 450: YLDGSGAQTL ; VNTEINDPDG ; IAVDWVARNL ; YWTDTGTDRI ; EVTRLNGTSR ; 500: KILVSEDLDE ; PRAIALHPVM ; GLMYWTDWGE ; NPKIECANLD ; GQERRVLVNA ; 550: SLGWPNGLAL ; DLQEGKLYWG ; DAKTDKIEVI ; NVDGTKRRTL ; LEDKLPHIFG ; 600: FTLLGDFIYW ; TDWQRRSIER ; VHKVKASRDV ; IIDQLPDLMG ; LKAVNVAKVV ; 650: GTNPCADRNG ; GCSHLCFFTP ; HATRCGCPIG ; LELLSDMKTC ; IVPEAFLVFT ; 700: SRAAIHRISL ; ETNNNDVAIP ; LTGVKEASAL ; DFDVSNNHIY ; WTDVSLKTIS ; 750: RAFMNGSSVE ; HVVEFGLDYP ; EGMAVDWMGK ; NLYWADTGTN ; RIEVARLDGQ ; 800: FRQVLVWRDL ; DNPRSLALDP ; TKGYIYWTEW ; GGKPRIVRAF ; MDGTNCMTLV ; 850: DKVGRANDLT ; IDYADQRLYW ; TDLDTNMIES ; SNMLGQERVV ; IADDLPHPFG ; 900: LTQYSDYIYW ; TDWNLHSIER ; ADKTSGRNRT ; LIQGHLDFVM ; DILVFHSSRQ ; 950: DGLNDCMHNN ; GQCGQLCLAI ; PGGHRCGCAS ; HYTLDPSSRN ; CSPPTTFLLF ; 1000: SQKSAISRMI ; PDDQHSPDLI ; LPLHGLRNVK ; AIDYDPLDKF ; IYWVDGRQNI ; 1050: KRAKDDGTQP ; FVLTSLSQGQ ; NPDRQPHDLS ; IDIYSRTLFW ; TCEATNTINV ; 1100: HRLSGEAMGV ; VLRGDRDKPR ; AIVVNAERGY ; LYFTNMQDRA ; AKIERAALDG ; 1150: TEREVLFTTG ; LIRPVALVVD ; NTLGKLFWVD ; ADLKRIESCD ; LSGANRLTLE ; 1200: DANIVQPLGL ; TILGKHLYWI ; DRQQQMIERV ; EKTTGDKRTR ; IQGRVAHLTG ; 1250: IHAVEEVSLE ; EFSAHPCARD ; NGGCSHICIA ; KGDGTPRCSC ; PVHLVLLQNL ; 1300: LTCGEPPTCS ; PDQFACATGE ; IDCIPGAWRC ; DGFPECDDQS ; DEEGCPVCSA ; 1350: AQFPCARGQC ; VDLRLRCDGE ; ADCQDRSDEA ; DCDAICLPNQ ; FRCASGQCVL ; 1400: IKQQCDSFPD ; CIDGSDELMC ; EITKPPSDDS ; PAHSSAIGPV ; IGIILSLFVM ; 1450: GGVYFVCQRV ; VCQRYAGANG ; PFPHEYVSGT ; PHVPLNFIAP ; GGSQHGPFTG ; 1500: IACGKSMMSS ; VSLMGGRGGV ; PLYDRNHVTG ; ASSSSSSSTK ; ATLYPPILNP ; 1550: PPSPATDPSL ; YNMDMFYSSN ; IPATARPYRP ; YIIRGMAPPT ; TPCSTDVCDS ; 1600: DYSASRWKAS ; KYYLDLNSDS ; DPYPPPPTPH ; SQYLSAEDSC ; PPSPATERSY ; 1615: FHLFPPPPSP ; CTDSS
Sequence Length	1615
String	O75197
Sub Unit	Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling (By similarity). Component of a Wnt-signaling complex that contains a WNT protein, a FZD protein and LRP5 or LRP6. Interacts with FZD8; the interaction is formed on WNT-binding and signaling. Interacts (via the phosphorylated PPPSP motif domains) with AXIN1; the interaction prevents inhibition of beta-catenin phosphorylation and signaling and is enhanced in the presence of GSK3B and WNT1 or WNT3A. Interacts (via beta-propeller regions 3 and 4) with DKK1; the interaction, enhanced by MESD and/or KREMEN, inhibits beta-catenin signaling by preventing GSK3-mediated phosphorylation of the PPPSP motifs and subsequent, AXIN1 binding. Interacts with MESD; the interaction prevents the formation of LRP5 aggregates, targets LRP5 to the plasma membrane and, when complexed with KREMEN2, increases DKK1 binding. Interacts with CSNK1E. Interacts with SOST; the interaction antagonizes canonical Wnt signaling. Interacts with APCDD1.

Uniprot	O75197
Gene Name	LRP5
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:4041
Unigene	Hs.6347

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806059	E3681h	96T	$736		Add to Cart

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