Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be intealized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its intealization in uninfected cells.
Specificity
Natural and recombinant Human Low-density lipoprotein receptor
Subcellular Location
Cell membrane Single-pass type I membrane protein Endomembrane system Single-pass type I membrane protein Membrane clathrin-coated pit Single-pass type I membrane protein Found distributed from the plasma membrane to intracellular compartments.