Solute carrier family 27 member 1 ; ACSVL5 ; FATP1
Categories
Elisa
Function
Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alteatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.
Specificity
Natural and recombinant Human Long-chain fatty acid transport protein 1
Subcellular Location
Cell membrane Single-pass membrane protein Endomembrane system Single-pass membrane protein Cytoplasm Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes.