Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Specificity
Natural and recombinant Human Leukocyte immunoglobulin-like receptor subfamily B member 1
Subcellular Location
Membrane Single-pass type I membrane protein
Detection Range
31.2-2000pg/mL
Entryname
LIRB1_HUMAN
Method Type
Sandwich
Protein Name
Leukocyte immunoglobulin-like receptor subfamily B member 1