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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Leukocyte-associated immunoglobulin-like receptor 1

SKU : BHE13806559

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E9027h
Alternative Names	CD305 ; CD305
Categories	Elisa
Function	Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
Specificity	Natural and recombinant Human Leukocyte-associated immunoglobulin-like receptor 1
Subcellular Location	Cell membrane Single-pass type I membrane protein
Detection Range	0.156-10ng/mL
Entryname	LAIR1_HUMAN
Method Type	Sandwich
Protein Name	Leukocyte-associated immunoglobulin-like receptor 1
Sensitivity	0.067ng/mL
Sequence	50: MSPHPTALLG ; LVLCLAQTIH ; TQEEDLPRPS ; ISAEPGTVIP ; LGSHVTFVCR ; 100: GPVGVQTFRL ; ERESRSTYND ; TEDVSQASPS ; ESEARFRIDS ; VSEGNAGPYR ; 150: CIYYKPPKWS ; EQSDYLELLV ; KETSGGPDSP ; DTEPGSSAGP ; TQRPSDNSHN ; 200: EHAPASQGLK ; AEHLYILIGV ; SVVFLFCLLL ; LVLFCLHRQN ; QIKQGPPRSK ; 250: DEEQKPQQRP ; DLAVDVLERT ; ADKATVNGLP ; EKDRETDTSA ; LAAGSSQEVT ; 287: YAQLDHWALT ; QRTARAVSPQ ; STKPMAESIT ; YAAVARH
Sequence Length	287
String	Q6GTX8
Sub Unit	Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK.

Uniprot	Q6GTX8
Gene Name	LAIR1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3903
Unigene	Hs.572535

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806559	E9027h	96T	$736		Add to Cart

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