La ribonucleoprotein domain family member 7 ; P-TEFb-interaction protein for 7SK stability ; PIP7S ; HDCMA18P
Categories
Elisa
Function
Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Specificity
Natural and recombinant Human La-related protein 7
Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.