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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Kinase suppressor of Ras 1

SKU : BHE13805726

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E14081h
Alternative Names	KSR
Categories	Elisa
Function	Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
Specificity	Natural and recombinant Human Kinase suppressor of Ras 1
Subcellular Location	Cytoplasm Membrane Peripheral membrane protein Endoplasmic reticulum membrane In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery.
Detection Range	0.312-20ng/ml
Entryname	KSR1_HUMAN
Method Type	Sandwich
Platform	PF13543
Protein Name	Kinase suppressor of Ras 1
Sensitivity	0.19ng/mL
Sequence	50: MDRAALRAAA ; MGEKKEGGGG ; GDAAEGGAGA ; AASRALQQCG ; QLQKLIDISI ; 100: GSLRGLRTKC ; AVSNDLTQQE ; IRTLEAKLVR ; YICKQRQCKL ; SVAPGERTPE ; 150: LNSYPRFSDW ; LYTFNVRPEV ; VQEIPRDLTL ; DALLEMNEAK ; VKETLRRCGA ; 200: SGDECGRLQY ; ALTCLRKVTG ; LGGEHKEDSS ; WSSLDARRES ; GSGPSTDTLS ; 250: AASLPWPPGS ; SQLGRAGNSA ; QGPRSISVSA ; LPASDSPTPS ; FSEGLSDTCI ; 300: PLHASGRLTP ; RALHSFITPP ; TTPQLRRHTK ; LKPPRTPPPP ; SRKVFQLLPS ; 350: FPTLTRSKSH ; ESQLGNRIDD ; VSSMRFDLSH ; GSPQMVRRDI ; GLSVTHRFST ; 400: KSWLSQVCHV ; CQKSMIFGVK ; CKHCRLKCHN ; KCTKEAPACR ; ISFLPLTRLR ; 450: RTESVPSDIN ; NPVDRAAEPH ; FGTLPKALTK ; KEHPPAMNHL ; DSSSNPSSTT ; 500: SSTPSSPAPF ; PTSSNPSSAT ; TPPNPSPGQR ; DSRFNFPAAY ; FIHHRQQFIF ; 550: PVPSAGHCWK ; CLLIAESLKE ; NAFNISAFAH ; AAPLPEAADG ; TRLDDQPKAD ; 600: VLEAHEAEAE ; EPEAGKSEAE ; DDEDEVDDLP ; SSRRPWRGPI ; SRKASQTSVY ; 650: LQEWDIPFEQ ; VELGEPIGQG ; RWGRVHRGRW ; HGEVAIRLLE ; MDGHNQDHLK ; 700: LFKKEVMNYR ; QTRHENVVLF ; MGACMNPPHL ; AIITSFCKGR ; TLHSFVRDPK ; 750: TSLDINKTRQ ; IAQEIIKGMG ; YLHAKGIVHK ; DLKSKNVFYD ; NGKVVITDFG ; 800: LFGISGVVRE ; GRRENQLKLS ; HDWLCYLAPE ; IVREMTPGKD ; EDQLPFSKAA ; 850: DVYAFGTVWY ; ELQARDWPLK ; NQAAEASIWQ ; IGSGEGMKRV ; LTSVSLGKEV ; 900: SEILSACWAF ; DLQERPSFSL ; LMDMLEKLPK ; LNRRLSHPGH ; FWKSAEINSS ; 921: KVVPRFERFG ; LGVLESSNPK ; M
Sequence Length	921
String	Q8IVT5
Sub Unit	Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization. Interacts with isoform 1 of VRK2.

Uniprot	Q8IVT5
Gene Name	KSR1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:8844
Unigene	Hs.133534

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805726	E14081h	96T	$736		Add to Cart

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