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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Interleukin-4 receptor subunit alpha

SKU : BHE13805011

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2031h
Alternative Names	CD124 ; IL4RA ; 582J2.1
Categories	Elisa
Function	Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Specificity	Natural and recombinant Human Interleukin-4 receptor subunit alpha
Subcellular Location	Isoform 2 Secreted
Detection Range	15.6-1000pg/mL
Entryname	IL4RA_HUMAN
Method Type	Sandwich
Platform	PF09238
Protein Name	Interleukin-4 receptor subunit alpha
Sensitivity	7.5pg/mL
Sequence	50: MGWLCSGLLF ; PVSCLVLLQV ; ASSGNMKVLQ ; EPTCVSDYMS ; ISTCEWKMNG ; 100: PTNCSTELRL ; LYQLVFLLSE ; AHTCIPENNG ; GAGCVCHLLM ; DDVVSADNYT ; 150: LDLWAGQQLL ; WKGSFKPSEH ; VKPRAPGNLT ; VHTNVSDTLL ; LTWSNPYPPD ; 200: NYLYNHLTYA ; VNIWSENDPA ; DFRIYNVTYL ; EPSLRIAAST ; LKSGISYRAR ; 250: VRAWAQCYNT ; TWSEWSPSTK ; WHNSYREPFE ; QHLLLGVSVS ; CIVILAVCLL ; 300: CYVSITKIKK ; EWWDQIPNPA ; RSRLVAIIIQ ; DAQGSQWEKR ; SRGQEPAKCP ; 350: HWKNCLTKLL ; PCFLEHNMKR ; DEDPHKAAKE ; MPFQGSGKSA ; WCPVEISKTV ; 400: LWPESISVVR ; CVELFEAPVE ; CEEEEEVEEE ; KGSFCASPES ; SRDDFQEGRE ; 450: GIVARLTESL ; FLDLLGEENG ; GFCQQDMGES ; CLLPPSGSTS ; AHMPWDEFPS ; 500: AGPKEAPPWG ; KEQPLHLEPS ; PPASPTQSPD ; NLTCTETPLV ; IAGNPAYRSF ; 550: SNSLSQSPCP ; RELGPDPLLA ; RHLEEVEPEM ; PCVPQLSEPT ; TVPQPEPETW ; 600: EQILRRNVLQ ; HGAAAAPVSA ; PTSGYQEFVH ; AVEQGGTQAS ; AVVGLGPPGE ; 650: AGYKAFSSLL ; ASSAVSPEKC ; GFGASSGEEG ; YKPFQDLIPG ; CPGDPAPVPV ; 700: PLFTFGLDRE ; PPRSPQSSHL ; PSSSPEHLGL ; EPGEKVEDMP ; KPPLPQEQAT ; 750: DPLVDSLGSG ; IVYSALTCHL ; CGHLKQCHGQ ; EDGGQTPVMA ; SPCCGCCCGD ; 800: RSSPPTTPLR ; APDPSPGGVP ; LEASLCPASL ; APSGISEKSK ; SSSSFHPAPG ; 825: NAQSSSQTPK ; IVNFVSVGPT ; YMRVS
Sequence Length	825
String	P24394
Sub Unit	The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor. Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (By similarity). Interacts with JAK1 through a Box 1-containing region. In Th1 cells, binds the N-terminal 50 amino acids of SOCS5, which inhibits JAK1 interaction, STAT6 activation and Th2 cell differentiation. SOCS5 interaction is independent of tyrosine phosphorylation.

Uniprot	P24394
Gene Name	IL4R
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3566
Unigene	Hs.513457

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805011	E2031h	96T	$736		Add to Cart

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