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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Interleukin-37

SKU : BHE13806399

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10078h
Alternative Names	FIL1 zeta ; IL-1X ; Interleukin-1 family member 7 ; IL-1F7 ; Interleukin-1 homolog 4 ; IL-1H ; Interleukin-1 zeta ; IL-1 zeta ; Interleukin-1-related protein ; IL-1RP1 ; Interleukin-23 ; IL-37 ; FIL1Z ; IL1F7 ; IL1H4 ; IL1RP1
Categories	Elisa
Function	Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Specificity	Natural and recombinant Human Interleukin-37
Subcellular Location	Cytoplasm cytosol Nucleus Secreted Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions. Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation.
Detection Range	31.2-2000pg/mL
Entryname	IL37_HUMAN
Method Type	Sandwich
Platform	PF00340
Protein Name	Interleukin-37
Sensitivity	12pg/mL
Sequence	50: MSFVGENSGV ; KMGSEDWEKD ; EPQCCLEDPA ; GSPLEPGPSL ; PTMNFVHTSP ; 100: KVKNLNPKKF ; SIHDQDHKVL ; VLDSGNLIAV ; PDKNYIRPEI ; FFALASSLSS ; 150: ASAEKGSPIL ; LGVSKGEFCL ; YCDKDKGQSH ; PSLQLKKEKL ; MKLAAQKESA ; 200: RRPFIFYRAQ ; VGSWNMLESA ; AHPGWFICTS ; CNCNEPVGVT ; DKFENRKHIE ; 218: FSFQPVCKAE ; MSPSEVSD
Sequence Length	218
String	Q9NZH6
Sub Unit	Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18.

Uniprot	Q9NZH6
Gene Name	IL37
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:27178
Unigene	Hs.166371

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806399	E10078h	96T	$736		Add to Cart

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