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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Interleukin-1 receptor-associated kinase 1

SKU : BHE13806513

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1514h
Alternative Names	IRAK
Categories	Elisa
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-TAK1/NR2C2-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, TAK1/NR2C2 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.
Specificity	Natural and recombinant Human Interleukin-1 receptor-associated kinase 1
Subcellular Location	Cytoplasm Nucleus Translocates to the nucleus when sumoylated.
Detection Range	0.156-10ng/mL
Entryname	IRAK1_HUMAN
Method Type	Sandwich
Platform	PF00531
Protein Name	Interleukin-1 receptor-associated kinase 1
Sensitivity	0.078ng/mL
Sequence	50: MAGGPGPGEP ; AAPGAQHFLY ; EVPPWVMCRF ; YKVMDALEPA ; DWCQFAALIV ; 100: RDQTELRLCE ; RSGQRTASVL ; WPWINRNARV ; ADLVHILTHL ; QLLRARDIIT ; 150: AWHPPAPLPS ; PGTTAPRPSS ; IPAPAEAEAW ; SPRKLPSSAS ; TFLSPAFPGS ; 200: QTHSGPELGL ; VPSPASLWPP ; PPSPAPSSTK ; PGPESSVSLL ; QGARPFPFCW ; 250: PLCEISRGTH ; NFSEELKIGE ; GGFGCVYRAV ; MRNTVYAVKR ; LKENADLEWT ; 300: AVKQSFLTEV ; EQLSRFRHPN ; IVDFAGYCAQ ; NGFYCLVYGF ; LPNGSLEDRL ; 350: HCQTQACPPL ; SWPQRLDILL ; GTARAIQFLH ; QDSPSLIHGD ; IKSSNVLLDE ; 400: RLTPKLGDFG ; LARFSRFAGS ; SPSQSSMVAR ; TQTVRGTLAY ; LPEEYIKTGR ; 450: LAVDTDTFSF ; GVVVLETLAG ; QRAVKTHGAR ; TKYLKDLVEE ; EAEEAGVALR ; 500: STQSTLQAGL ; AADAWAAPIA ; MQIYKKHLDP ; RPGPCPPELG ; LGLGQLACCC ; 550: LHRRAKRRPP ; MTQVYERLEK ; LQAVVAGVPG ; HSEAASCIPP ; SPQENSYVSS ; 600: TGRAHSGAAP ; WQPLAAPSGA ; SAQAAEQLQR ; GPNQPVESDE ; SLGGLSAALR ; 650: SWHLTPSCPL ; DPAPLREAGC ; PQGDTAGESS ; WGSGPGSRPT ; AVEGLALGSS ; 700: ASSSSEPPQI ; IINPARQKMV ; QKLALYEDGA ; LDSLQLLSSS ; SLPGLGLEQD ; 712: RQGPEESDEF ; QS
Sequence Length	712
String	P51617
Sub Unit	Homodimer (By similarity). Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation. Interacts with MYD88; this interaction recruits IRAK1 to the stimulated receptor complex. Interacts with IL1RL1. Interacts with IRAK1BP1 (By similarity). Associates with TRAF6, PELI1 and IRAK4; this complex recruits TAK1/NR2C2, TAB1 and TAB2 to mediate NF-kappa-B activation. Interacts (when polyubiquitinated) with IKBKG/NEMO.

Uniprot	P51617
Gene Name	IRAK1
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3654
Unigene	Hs.522819

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SKU	Supplier No.	Size	Your price	Quantity
BHE13806513	E1514h	96T	$736		Add to Cart

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