Cytokine receptor class-II member 1 ; Cytokine receptor family 2 member 1 ; CRF2-1 ; Type I interferon receptor 1 ; IFNAR
Categories
Elisa
Function
Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves.
Specificity
Natural and recombinant Human Interferon alpha/beta receptor 1
Subcellular Location
Isoform 1 Membrane Single-pass type I membrane protein
Heterodimer with IFNAR2; in presence of interferon alpha and beta ligands, the heterodimer forms the type I interferon receptor. Interacts with STAT1 and STAT2; the interaction requires its phosphorylation at Tyr-466. Interacts with IFNAR2.