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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Insulin receptor

SKU : BHE13805705

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E0895h
Alternative Names	CD220
Categories	Elisa
Function	This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. Mediates the metabolic functions of insulin. Binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). Can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Specificity	Natural and recombinant Human Insulin receptor
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	1.56-100ng/mL
Entryname	INSR_HUMAN
Method Type	Sandwich
Platform	PF00041
Protein Name	Insulin receptor
Sensitivity	0.061ng/mL
Sequence	50: MATGGRRGAA ; AAPLLVAVAA ; LLLGAAGHLY ; PGEVCPGMDI ; RNNLTRLHEL ; 100: ENCSVIEGHL ; QILLMFKTRP ; EDFRDLSFPK ; LIMITDYLLL ; FRVYGLESLK ; 150: DLFPNLTVIR ; GSRLFFNYAL ; VIFEMVHLKE ; LGLYNLMNIT ; RGSVRIEKNN ; 200: ELCYLATIDW ; SRILDSVEDN ; YIVLNKDDNE ; ECGDICPGTA ; KGKTNCPATV ; 250: INGQFVERCW ; THSHCQKVCP ; TICKSHGCTA ; EGLCCHSECL ; GNCSQPDDPT ; 300: KCVACRNFYL ; DGRCVETCPP ; PYYHFQDWRC ; VNFSFCQDLH ; HKCKNSRRQG ; 350: CHQYVIHNNK ; CIPECPSGYT ; MNSSNLLCTP ; CLGPCPKVCH ; LLEGEKTIDS ; 400: VTSAQELRGC ; TVINGSLIIN ; IRGGNNLAAE ; LEANLGLIEE ; ISGYLKIRRS ; 450: YALVSLSFFR ; KLRLIRGETL ; EIGNYSFYAL ; DNQNLRQLWD ; WSKHNLTITQ ; 500: GKLFFHYNPK ; LCLSEIHKME ; EVSGTKGRQE ; RNDIALKTNG ; DQASCENELL ; 550: KFSYIRTSFD ; KILLRWEPYW ; PPDFRDLLGF ; MLFYKEAPYQ ; NVTEFDGQDA ; 600: CGSNSWTVVD ; IDPPLRSNDP ; KSQNHPGWLM ; RGLKPWTQYA ; IFVKTLVTFS ; 650: DERRTYGAKS ; DIIYVQTDAT ; NPSVPLDPIS ; VSNSSSQIIL ; KWKPPSDPNG ; 700: NITHYLVFWE ; RQAEDSELFE ; LDYCLKGLKL ; PSRTWSPPFE ; SEDSQKHNQS ; 750: EYEDSAGECC ; SCPKTDSQIL ; KELEESSFRK ; TFEDYLHNVV ; FVPRKTSSGT ; 800: GAEDPRPSRK ; RRSLGDVGNV ; TVAVPTVAAF ; PNTSSTSVPT ; SPEEHRPFEK ; 850: VVNKESLVIS ; GLRHFTGYRI ; ELQACNQDTP ; EERCSVAAYV ; SARTMPEAKA ; 900: DDIVGPVTHE ; IFENNVVHLM ; WQEPKEPNGL ; IVLYEVSYRR ; YGDEELHLCV ; 950: SRKHFALERG ; CRLRGLSPGN ; YSVRIRATSL ; AGNGSWTEPT ; YFYVTDYLDV ; 1000: PSNIAKIIIG ; PLIFVFLFSV ; VIGSIYLFLR ; KRQPDGPLGP ; LYASSNPEYL ; 1050: SASDVFPCSV ; YVPDEWEVSR ; EKITLLRELG ; QGSFGMVYEG ; NARDIIKGEA ; 1100: ETRVAVKTVN ; ESASLRERIE ; FLNEASVMKG ; FTCHHVVRLL ; GVVSKGQPTL ; 1150: VVMELMAHGD ; LKSYLRSLRP ; EAENNPGRPP ; PTLQEMIQMA ; AEIADGMAYL ; 1200: NAKKFVHRDL ; AARNCMVAHD ; FTVKIGDFGM ; TRDIYETDYY ; RKGGKGLLPV ; 1250: RWMAPESLKD ; GVFTTSSDMW ; SFGVVLWEIT ; SLAEQPYQGL ; SNEQVLKFVM ; 1300: DGGYLDQPDN ; CPERVTDLMR ; MCWQFNPKMR ; PTFLEIVNLL ; KDDLHPSFPE ; 1350: VSFFHSEENK ; APESEELEME ; FEDMENVPLD ; RSSHCQREEA ; GGRDGGSSLG ; 1382: FKRSYEEHIP ; YTHMNGGKKN ; GRILTLPRSN ; PS
Sequence Length	1382
String	P06213
Sub Unit	Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Binds SH2B2. Interacts with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. The sequences surrounding the phosphorylated NPXY motif contribute differentially to either IRS1 or SHC1 recognition. Interacts with the SH2 domains of the 85 kDa regulatory subunit of PI3K (PIK3R1) in vitro, when autophosphorylated on tyrosine residues. Interacts with SOCS7. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with CAV2 (tyrosine-phosphorylated form); the interaction is increased with 'Tyr-27'phosphorylation of CAV2. Interacts with ARRB2 (By similarity). Interacts with GRB10; this interaction blocks the association between IRS1/IRS2 and INSR, significantly reduces insulin-stimulated tyrosine phosphorylation of IRS1 and IRS2 and thus decreases insulin signaling. Interacts with GRB7.

Uniprot	P06213
Gene Name	INSR
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3643
Unigene	Hs.465744

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805705	E0895h	96T	$736		Add to Cart

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