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ELISA Kit for Human Insulin-like growth factor 1 receptor

SKU : BHE13805627

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1200h
Alternative Names	Insulin-like growth factor I receptor ; IGF-I receptor ; CD221
Categories	Elisa
Function	This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.
Specificity	Natural and recombinant Human Insulin-like growth factor 1 receptor
Subcellular Location	Membrane Single-pass type I membrane protein
Detection Range	0.312-20ng/mL
Entryname	IGF1R_HUMAN
Method Type	Sandwich
Platform	PF00041
Protein Name	Insulin-like growth factor 1 receptor
Sensitivity	0.098ng/mL
Sequence	50: MKSGSGGGSP ; TSLWGLLFLS ; AALSLWPTSG ; EICGPGIDIR ; NDYQQLKRLE ; 100: NCTVIEGYLH ; ILLISKAEDY ; RSYRFPKLTV ; ITEYLLLFRV ; AGLESLGDLF ; 150: PNLTVIRGWK ; LFYNYALVIF ; EMTNLKDIGL ; YNLRNITRGA ; IRIEKNADLC ; 200: YLSTVDWSLI ; LDAVSNNYIV ; GNKPPKECGD ; LCPGTMEEKP ; MCEKTTINNE ; 250: YNYRCWTTNR ; CQKMCPSTCG ; KRACTENNEC ; CHPECLGSCS ; APDNDTACVA ; 300: CRHYYYAGVC ; VPACPPNTYR ; FEGWRCVDRD ; FCANILSAES ; SDSEGFVIHD ; 350: GECMQECPSG ; FIRNGSQSMY ; CIPCEGPCPK ; VCEEEKKTKT ; IDSVTSAQML ; 400: QGCTIFKGNL ; LINIRRGNNI ; ASELENFMGL ; IEVVTGYVKI ; RHSHALVSLS ; 450: FLKNLRLILG ; EEQLEGNYSF ; YVLDNQNLQQ ; LWDWDHRNLT ; IKAGKMYFAF ; 500: NPKLCVSEIY ; RMEEVTGTKG ; RQSKGDINTR ; NNGERASCES ; DVLHFTSTTT ; 550: SKNRIIITWH ; RYRPPDYRDL ; ISFTVYYKEA ; PFKNVTEYDG ; QDACGSNSWN ; 600: MVDVDLPPNK ; DVEPGILLHG ; LKPWTQYAVY ; VKAVTLTMVE ; NDHIRGAKSE ; 650: ILYIRTNASV ; PSIPLDVLSA ; SNSSSQLIVK ; WNPPSLPNGN ; LSYYIVRWQR ; 700: QPQDGYLYRH ; NYCSKDKIPI ; RKYADGTIDI ; EEVTENPKTE ; VCGGEKGPCC ; 750: ACPKTEAEKQ ; AEKEEAEYRK ; VFENFLHNSI ; FVPRPERKRR ; DVMQVANTTM ; 800: SSRSRNTTAA ; DTYNITDPEE ; LETEYPFFES ; RVDNKERTVI ; SNLRPFTLYR ; 850: IDIHSCNHEA ; EKLGCSASNF ; VFARTMPAEG ; ADDIPGPVTW ; EPRPENSIFL ; 900: KWPEPENPNG ; LILMYEIKYG ; SQVEDQRECV ; SRQEYRKYGG ; AKLNRLNPGN ; 950: YTARIQATSL ; SGNGSWTDPV ; FFYVQAKTGY ; ENFIHLIIAL ; PVAVLLIVGG ; 1000: LVIMLYVFHR ; KRNNSRLGNG ; VLYASVNPEY ; FSAADVYVPD ; EWEVAREKIT ; 1050: MSRELGQGSF ; GMVYEGVAKG ; VVKDEPETRV ; AIKTVNEAAS ; MRERIEFLNE ; 1100: ASVMKEFNCH ; HVVRLLGVVS ; QGQPTLVIME ; LMTRGDLKSY ; LRSLRPEMEN ; 1150: NPVLAPPSLS ; KMIQMAGEIA ; DGMAYLNANK ; FVHRDLAARN ; CMVAEDFTVK ; 1200: IGDFGMTRDI ; YETDYYRKGG ; KGLLPVRWMS ; PESLKDGVFT ; TYSDVWSFGV ; 1250: VLWEIATLAE ; QPYQGLSNEQ ; VLRFVMEGGL ; LDKPDNCPDM ; LFELMRMCWQ ; 1300: YNPKMRPSFL ; EIISSIKEEM ; EPGFREVSFY ; YSEENKLPEP ; EELDLEPENM ; 1350: ESVPLDPSAS ; SSSLPLPDRH ; SGHKAENGPG ; PGVLVLRASF ; DERQPYAHMN ; 1367: GGRKNERALP ; LPQSSTC
Sequence Length	1367
String	P08069
Sub Unit	Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Forms a hybrid receptor with INSR, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with GNB2L1/RACK1.

Uniprot	P08069
Gene Name	IGF1R
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:3480
Unigene	Hs.643120

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805627	E1200h	96T	$736		Add to Cart

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