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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Hypoxia-inducible factor 3-alpha

SKU : BHE13805187

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E10271h
Alternative Names	Basic-helix-loop-helix-PAS protein MOP7 ; Class E basic helix-loop-helix protein 17 ; bHLHe17 ; HIF3-alpha-1 ; Inhibitory PAS domain protein ; IPAS ; Member of PAS protein 7 ; PAS domain-containing protein 7 ; BHLHE17 ; MOP7 ; PASD7
Categories	Elisa
Function	Involved in adaptive response to hypoxia. Suppresses hypoxia-inducible expression of HIF1A and EPAS1. Binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters. The complex HIF3A-ARNT activates the transcription of reporter genes driven by HRE. Isoform 4 has a dominant-negative function of inactivating HIF1A-mediated transcription. Isoform 4 attenuates the binding of HIF1A to hypoxia-responsive elements (HRE), thus inhibiting HRE-driven transcription. Hypoxia induces down-regulation of isoform 4, leading to activation of HIF1A in hypoxia. Conversely, upon restoring normoxia, the expression of isoform 4 increases and thereby secure an inhibition of HIF1A activity. Isoform 4 may be a negative regulator of hypoxia-inducible gene expression in the kidney and may be involved in renal tumorigenesis. Functions as an inhibitor of angiogenesis in the coea.
Specificity	Natural and recombinant Human Hypoxia-inducible factor 3-alpha
Subcellular Location	Nucleus Cytoplasm In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes.
Detection Range	78-5000pg/ml
Entryname	HIF3A_HUMAN
Method Type	Sandwich
Platform	PF11413
Protein Name	Hypoxia-inducible factor 3-alpha
Sensitivity	39.1pg/mL
Sequence	50: MALGLQRARS ; TTELRKEKSR ; DAARSRRSQE ; TEVLYQLAHT ; LPFARGVSAH ; 100: LDKASIMRLT ; ISYLRMHRLC ; AAGEWNQVGA ; GGEPLDACYL ; KALEGFVMVL ; 150: TAEGDMAYLS ; ENVSKHLGLS ; QLELIGHSIF ; DFIHPCDQEE ; LQDALTPQQT ; 200: LSRRKVEAPT ; ERCFSLRMKS ; TLTSRGRTLN ; LKAATWKVLN ; CSGHMRAYKP ; 250: PAQTSPAGSP ; DSEPPLQCLV ; LICEAIPHPG ; SLEPPLGRGA ; FLSRHSLDMK ; 300: FTYCDDRIAE ; VAGYSPDDLI ; GCSAYEYIHA ; LDSDAVSKSI ; HTLLSKGQAV ; 350: TGQYRFLARS ; GGYLWTQTQA ; TVVSGGRGPQ ; SESIVCVHFL ; ISQVEETGVV ; 400: LSLEQTEQHS ; RRPIQRGAPS ; QKDTPNPGDS ; LDTPGPRILA ; FLHPPSLSEA ; 450: ALAADPRRFC ; SPDLRRLLGP ; ILDGASVAAT ; PSTPLATRHP ; QSPLSADLPD ; 500: ELPVGTENVH ; RLFTSGKDTE ; AVETDLDIAQ ; DADALDLEML ; APYISMDDDF ; 550: QLNASEQLPR ; AYHRPLGAVP ; RPRARSFHGL ; SPPALEPSLL ; PRWGSDPRLS ; 600: CSSPSRGDPS ; ASSPMAGARK ; RTLAQSSEDE ; DEGVELLGVR ; PPKRSPSPEH ; 650: ENFLLFPLSL ; SFLLTGGPAP ; GSLQDPSTPL ; LNLNEPLGLG ; PSLLSPYSDE ; 669: DTTQPGGPFQ ; PRAGSAQAD
Sequence Length	669
String	Q9Y2N7
Sub Unit	Heterodimerizes with ARNT. Interacts via the oxygen-dependent degradation domain (ODD) with the beta domain of VHL.

Uniprot	Q9Y2N7
Gene Name	HIF3A
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:64344
Unigene	Hs.420830

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805187	E10271h	96T	$736		Add to Cart

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