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Home / Assay Kits / ELISA Kits

ELISA Kit for Human Holliday junction recognition protein

SKU : BHE13805547

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E2156h
Alternative Names	14-3-3-associated AKT substrate ; Fetal liver-expressing gene 1 protein ; Up-regulated in lung cancer 9 ; FAKTS ; FLEG1 ; URLC9
Categories	Elisa
Function	Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Specificity	Natural and recombinant Human Holliday junction recognition protein
Subcellular Location	Nucleus nucleolus Chromosome centromere Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
Detection Range	0.625-40ng/mL
Entryname	HJURP_HUMAN
Method Type	Sandwich
Platform	PF12347
Protein Name	Holliday junction recognition protein
Sensitivity	0.314ng/mL
Sequence	50: MLGTLRAMEG ; EDVEDDQLLQ ; KLRASRRRFQ ; RRMQRLIEKY ; NQPFEDTPVV ; 100: QMATLTYETP ; QGLRIWGGRL ; IKERNEGEIQ ; DSSMKPADRT ; DGSVQAAAWG ; 150: PELPSHRTVL ; GADSKSGEVD ; ATSDQEESVA ; WALAPAVPQS ; PLKNELRRKY ; 200: LTQVDILLQG ; AEYFECAGNR ; AGRDVRVTPL ; PSLASPAVPA ; PGYCSRISRK ; 250: SPGDPAKPAS ; SPREWDPLHP ; SSTDMALVPR ; NDSLSLQETS ; SSSFLSSQPF ; 300: EDDDICNVTI ; SDLYAGMLHS ; MSRLLSTKPS ; SIISTKTFIM ; QNWNSRRRHR ; 350: YKSRMNKTYC ; KGARRSQRSS ; KENFIPCSEP ; VKGTGALRDC ; KNVLDVSCRK ; 400: TGLKLEKAFL ; EVNRPQIHKL ; DPSWKERKVT ; PSKYSSLIYF ; DSSATYNLDE ; 450: ENRFRTLKWL ; ISPVKIVSRP ; TIRQGHGENR ; QREIEIRFDQ ; LHREYCLSPR ; 500: NQPRRMCLPD ; SWAMNMYRGG ; PASPGGLQGL ; ETRRLSLPSS ; KAKAKSLSEA ; 550: FENLGKRSLE ; AGRCLPKSDS ; SSSLPKTNPT ; HSATRPQQTS ; DLHVQGNSSG ; 600: IFRKSVSPSK ; TLSVPDKEVP ; GHGRNRYDEI ; KEEFDKLHQK ; YCLKSPGQMT ; 650: VPLCIGVSTD ; KASMEVRYQT ; EGFLGKLNPD ; PHFQGFQKLP ; SSPLGCRKSL ; 700: LGSTAIEAPS ; STCVARAITR ; DGTRDHQFPA ; KRPRLSEPQG ; SGRQGNSLGA ; 748: SDGVDNTVRP ; GDQGSSSQPN ; SEERGENTSY ; RMEEKSDFML ; EKLETKSV
Sequence Length	748
String	Q8NCD3
Sub Unit	Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Interacts with 14-3-3 family members in a phosphorylation-dependent manner. Interacts with MSH5 and NBN.

Uniprot	Q8NCD3
Gene Name	HJURP
Immunogen Species	Homo Sapiens (Human)
Kegg	hsa:55355
Unigene	Hs.532968

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SKU	Supplier No.	Size	Your price	Quantity
BHE13805547	E2156h	96T	$736		Add to Cart

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